Bioprocess Configuration Using Unit Compatibility and Objective Functions

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Solution Overview

Problem

The existing methods for configuring bioprocessing systems are time-consuming and cumbersome due to the vast selection of bioprocessing units and units combinations, and they lack the ability to efficiently select units based on desired substance output and compatibility with existing systems.

Innovation Solution

A method and configuration system that recommends optimized combinations of bioprocessing units, including consumables and utility supply, by using requirement and unit data to optimize an objective function, which can be performed on a computer system already controlling the bioprocessing system or a third-party hosted system to maintain data confidentiality.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If a vast selection of bioprocessing units and combinations is used to provide desired system functionality, then system adaptability and versatility are improved, but device complexity and configuration time increase

Engineering Contradiction:
Improvesystem functionalityVSAvoidconfiguration complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent replaces manual configuration processes with an automated computer-based system that uses algorithms and software to select and configure bioprocessing units. The system automatically processes requirements, evaluates unit compatibility, and generates optimized configurations, eliminating the need for manual evaluation of vast unit combinations.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The configuration system performs self-service by automatically selecting appropriate bioprocessing units and determining their interconnections based on input requirements. The system independently evaluates compatibility, optimizes configurations, and generates complete system specifications without requiring external expert intervention for each configuration task.

Inventive Principle:
Principle #25Self-service

2Adaptability or versatility

If manual methods are used to identify suitable bioprocessing systems from vast selections, then configuration flexibility is maintained, but productivity and time efficiency decrease

Engineering Contradiction:
Improveconfiguration flexibilityVSAvoidconfiguration speed
Core Design Contradiction:
Adaptability or versatilityVSProductivity

Solution Approach 1:

The patent replaces manual configuration methods with an automated computer-based system that rapidly evaluates bioprocessing units and generates optimized configurations. The system processes requirements, selects appropriate units, and determines interconnections automatically, dramatically increasing configuration speed while maintaining flexibility through programmable evaluation criteria.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Reliability

If comprehensive system configuration is performed to ensure compatibility and optimize performance, then system reliability is improved, but loss of time and computational resources increases

Engineering Contradiction:
Improvesystem compatibilityVSAvoidconfiguration time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent implements preliminary action by pre-storing bioprocessing unit data, specifications, and compatibility information in databases before configuration is needed. The system retrieves and evaluates this pre-prepared data during configuration, avoiding the need to gather and analyze information from scratch for each configuration task, thus reducing time while ensuring comprehensive compatibility checking.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentUS12360498B2Method for optimization of a bioprocessing system
Publication Date: 2025.07.15 CYTIVA SWEDEN AB
  • US12360498B2 patent drawing
  • US12360498B2 patent drawing
  • US12360498B2 patent drawing

AI summary

The present invention relates to a computer implemented method (600) for optimization of a bioprocessing system (100) formed by interconnected or interconnectable bioprocessing units and configured to provide a desired system functionality, the method comprising obtaining (610) requirement data of a bioprocess, the requirement data being at least indicative of the desired system functionality, and indicative of a desired substance resulting from the operation of the bioprocess system, obtaining (620) unit data indicative of characteristics of a plurality of bioprocessing units, generating (630) at least one optimized or suitable bioprocessing system configuration capable to provide the desired system functionality, the bioprocessing system configuration comprising a selection of bioprocessing units from the plurality of bioprocessing units selected using the requirement data, the unit data and an objective function dependent on the requirement data and the unit data. The invention extends to a configuration system (500).