Biopsy Needle Spectroscopy for In Situ Tissue Classification
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Solution Overview
Problem
Current core needle biopsy (CNB) procedures often result in non-diagnostic samples due to insufficient diagnostic tissue, leading to repeated procedures and potential complications, and the advent of molecular pathology tests requires more tissue, delaying diagnosis and increasing patient risk.
Innovation Solution
A spectroscopy system and method that classifies tissue samples by receiving signals from chromophores, verifying the presence of attenuated and re-emitted light, processing the spectrum to decompose signals into components, and determining tissue types without removing the biopsy specimen from the needle, allowing for immediate characterization of diagnostic tissue quality and quantity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If core needle biopsy is performed to obtain tissue sample, then minimally invasive procedure is achieved, but insufficient diagnostic tissue is obtained leading to non-diagnostic samples
Solution Approach 1:
The spectroscopy system performs preliminary assessment of tissue characteristics before and during the biopsy procedure, allowing real-time verification of diagnostic tissue quality without requiring removal of the specimen for analysis
Solution Approach 2:
The patent replaces mechanical histopathological analysis with optical spectroscopy analysis, enabling non-invasive, real-time tissue characterization that does not require physical removal or extensive processing of the biopsy specimen
2Loss of information
If biopsy specimen is removed from needle for analysis, then tissue classification is performed, but tissue stress increases and diagnostic quality may deteriorate
Solution Approach 1:
The biopsy needle itself serves as the analysis platform, with the spectroscopy system directly analyzing tissue within the needle without requiring removal or transfer to separate processing equipment
Solution Approach 2:
Optical spectroscopy serves as an intermediary method that extracts diagnostic information from tissue without physical removal, using light interaction as a non-contact measurement medium
3Quantity of substance
If repeated biopsy procedures are performed to obtain adequate tissue, then sufficient diagnostic tissue is obtained, but patient complications increase
Solution Approach 1:
Real-time spectroscopy analysis during the biopsy procedure provides preliminary confirmation of adequate tissue quality, preventing the need for repeat procedures and associated complications
Solution Approach 2:
The system provides immediate feedback on tissue diagnostic quality through spectroscopy analysis, allowing adjustment of the biopsy procedure to ensure adequate sample quality before completing the procedure
4Adaptability or versatility
If molecular pathology tests are performed requiring larger tissue amount, then comprehensive testing is enabled, but diagnosis time is delayed
Solution Approach 1:
Spectroscopy analysis is performed preliminarily and simultaneously with biopsy procurement, providing immediate tissue characterization without adding sequential processing time
Solution Approach 2:
The spectroscopy analysis continues throughout the biopsy procedure rather than being a separate post-procedure step, maintaining continuous diagnostic information flow without interruption
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate classification and quantification of diagnostic tissue within the biopsy specimen in situ, reducing the need for repeated procedures, minimizing tissue stress, and streamlining workflow, while providing adequate tissue for molecular testing.
Implementation Method 1
receiving a signal from at least one location of the tissue sample including a plurality of chromophores
Implementation Method 2
verifying whether the received signal comprises a predetermined amount of at least one of an attenuated illumination light and a re-emitted light
Data Source
AI summary
A method for classifying a tissue sample of a biopsy specimen includes receiving a signal from at least one location of the tissue sample including a plurality of chromophores. Further, the method includes verifying whether the received signal comprises a predetermined amount of at least one of an attenuated illumination light and a re-emitted light. Also, the method includes determining that a spectrum of the received signal is within a predetermined range. In addition, the method includes processing the spectrum of the received signal to decompose the signal into a plurality of components. Furthermore, the method includes classifying tissue in the at least one location of the tissue sample into one of a plurality of tissue types based on the plurality of components.