Biopsy Tissue Sample Holder with Segmented Analysis
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Solution Overview
Problem
Current biopsy devices lack an efficient mechanism for individual tissue sample analysis and storage, particularly in a bulk configuration, which hinders the ability to analyze and manage tissue samples effectively during procedures.
Innovation Solution
A biopsy device with a tissue sample holder featuring a sample management assembly that includes a transparent sealing member, a sample basket, and a bulk tissue sample chamber, allowing for temporary isolation and analysis of individual tissue samples using bioimpedance sensors and visual inspection, with a mechanism to selectively communicate vacuum and fluid for sample collection and transport.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a traditional biopsy device is used to collect tissue samples, then the biopsy procedure can be completed, but the tissue samples cannot be individually analyzed or stored efficiently in bulk configuration
Solution Approach 1:
The tissue sample holder is nested within the biopsy device, with multiple sample chambers arranged in a compact configuration. Each chamber can individually hold and isolate tissue samples, allowing the device to maintain its original biopsy function while adding sample storage and analysis capabilities through the nested holder structure.
Solution Approach 2:
The sample holder is divided into multiple discrete sample chambers, each capable of holding and isolating individual tissue samples. This segmentation allows for independent analysis of each sample while maintaining bulk storage capability, resolving the contradiction between individual sample analysis and bulk configuration.
2Quantity of substance
If tissue samples are collected in bulk without individual isolation mechanism, then storage capacity is maximized, but individual sample analysis becomes difficult
Solution Approach 1:
The holder is segmented into multiple discrete chambers, each capable of containing individual tissue samples. This allows the device to store multiple samples in bulk configuration while enabling easy access and individual analysis of each sample by simply opening the specific chamber needed, without requiring to handle all samples.
Solution Approach 2:
The holder incorporates movable components that allow dynamic access to individual chambers while maintaining the overall bulk storage structure. This enables the operator to access and analyze specific samples individually while the remaining samples remain sealed and preserved in their bulk storage configuration.
3Reliability
If tissue samples adhere to the holder surfaces, then sample retention is improved, but sample removal and analysis become problematic
Solution Approach 1:
The holder chambers incorporate localized adhesion features only in specific areas where sample retention is needed, while other areas maintain non-adhesive surfaces to facilitate easy sample removal. This local differentiation of surface properties allows the holder to reliably retain samples during transport while enabling straightforward sample extraction for analysis when needed.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient analysis and storage of tissue samples, allowing for real-time analysis of individual samples during procedures and overcoming issues of sample adhesion, thereby improving the overall biopsy process.
Implementation Method 1
A biopsy device with a tissue sample holder featuring a sample management assembly that includes a transparent sealing member, a sample basket, and a bulk tissue sample chamber, allowing for temporary isolation and analysis of individual tissue samples using bioimpedance sensors and visual inspection, with a mechanism to selectively communicate vacuum and fluid for sample collection and transport.
Implementation Method 2
allowing for temporary isolation and analysis of individual tissue samples using bioimpedance sensors and visual inspection
Data Source
AI summary
A biopsy device includes a body, a needle, a cutter, an analysis area, a valve, and a tissue sample holder. The cutter is movable relative to the needle and in communication with the needle for transporting tissue samples. The analysis area is disposed proximally of the cutter and in communication with the needle to receive a tissue sample cut by the cutter for analysis by a user. The valve is disposed proximally of the analysis area and configured to alternate between an open configuration and a closed configuration. The tissue sample holder is disposed proximally of the valve and fixedly attached to the body. The valve is configured to permit analysis of the sample disposed in the analysis area when the valve is in the closed configuration and to permit the tissue sample to be passed into the tissue sample holder when the valve is in the open configuration configuration.