Bioreactor Acid Cleaning With In-Place pH Neutralization

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Solution Overview

Problem

Bioreactors face inefficiencies due to filter cake clogging, difficulty in determining optimal cleaning times, and challenges in recycling or neutralizing acid used for cleaning, particularly in compact systems like those on rail vehicles, where maintenance is decentralized and data access is limited.

Innovation Solution

A bioreactor cleaning system with a metering unit for acid and base canisters, a mixer, and pH sensors, allowing direct neutralization and disposal of used acid within the system, controlled by an electronic unit for efficient acid solution management.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If filter cake is removed early to prevent clogging, then filtration efficiency is maintained, but cleaning frequency increases and system productivity decreases

Engineering Contradiction:
Improvefiltration efficiencyVSAvoidsystem productivity
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The system uses pH sensors to continuously monitor the acid solution quality in the acid tank. When the pH value indicates the acid solution has become too neutral (pH > threshold), the control unit automatically triggers a cleaning cycle. This feedback mechanism ensures cleaning occurs only when necessary, maintaining filtration efficiency without excessive cleaning interruptions.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system monitors pH parameter changes in the acid solution to determine cleaning timing. By tracking the pH value as an indicator of acid solution effectiveness, the system can objectively determine when filter cake removal is necessary, avoiding both premature and delayed cleaning operations.

Inventive Principle:
Principle #35Parameter changes

2Reliability

If acid solution is used for cleaning bioreactor, then cleaning effectiveness is improved, but neutralization and disposal complexity increases

Engineering Contradiction:
Improvecleaning effectivenessVSAvoidneutralization and disposal complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The system combines the acid tank, base dosing unit, pH sensors, and neutralization chamber into an integrated cleaning system. The base is automatically dosed into the acid tank based on pH feedback, and the neutralized solution is automatically disposed of through the suction unit. This merging eliminates the need for separate neutralization stations and simplifies the overall process.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The system performs self-neutralization by automatically dosing base into the acid tank when pH exceeds the threshold. The control unit monitors pH continuously and triggers base addition without external intervention. This self-service capability reduces the need for external neutralization facilities and manual processing.

Inventive Principle:
Principle #25Self-service

3Reliability

If freshwater is used to rinse bioreactor after acid cleaning, then cleaning completeness is improved, but freshwater consumption increases

Engineering Contradiction:
Improvecleaning completenessVSAvoidfreshwater consumption
Core Design Contradiction:
ReliabilityVSLoss of substance

Solution Approach 1:

The system converts the potentially harmful acidic cleaning solution into a beneficial resource by neutralizing it in-place. The neutralized solution can then be safely disposed of through the existing waste disposal system. This eliminates the need for additional freshwater rinsing while ensuring safe disposal, effectively converting a waste problem into a resource recovery opportunity.

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

4Volume of moving object

If compact system design is implemented for rail vehicles, then space utilization is improved, but access for maintenance and data reading becomes difficult

Engineering Contradiction:
Improvespace utilizationVSAvoidmaintenance accessibility
Core Design Contradiction:
Volume of moving objectVSEase of operation

Solution Approach 1:

The suction unit serves multiple functions: it removes wastewater from the bioreactor, collects used acid solution from the cleaning process, and provides a pathway for disposing of neutralized cleaning solution. This multi-functionality reduces the need for separate access points and disposal facilities, maintaining compactness while ensuring operational accessibility.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables efficient use of acid for cleaning, reduces freshwater consumption, and ensures precise pH control for neutralization, facilitating decentralized maintenance without the need for external neutralization stations.

Implementation Method 1

aqueous acid solution to dissolve the filter cake

Methodology Applied
Scientific EffectChemical dissolution: Solvation

Implementation Method 2

dosing of base into the acid tank to neutralize the used acid solution

Methodology Applied
Scientific EffectNeutralization reaction: Redox Reactions

Data Source

PatentUS12577519B2Bioreactor cleaning system with an acid tank and a device for neutralizing the acid
Publication Date: 2026.03.17 VOGELSANG GMBH & CO KG
  • US12577519B2 patent drawing
  • US12577519B2 patent drawing
  • US12577519B2 patent drawing

AI summary

A bioreactor cleaning system for cleaning a bioreactor in a rail vehicle. A suction unit, a supply unit, an electronic control unit for actuating the suction unit and the supply unit, an acid tank, a collection tank for receiving a liquid suctioned out of the bioreactor, and a freshwater connection are provided. The bioreactor cleaning system comprises a metering unit which has acid canister connections, base canister connections, an acid metering device which can be connected to the acid canister connections and the acid tank, and a base metering device which can be connected to the base canister connections and the acid tank. Additionally, a mixer is provided in order to mix the different liquids.