Bioreactor Exhaust Condenser With Vortex Tube Filter Heating

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Solution Overview

Problem

Current bioreactor condensers require separate filter heaters to prevent condensation, increasing complexity and not addressing moisture issues effectively in bioreactor gas streams, which can lead to concentration imbalances in cell cultures.

Innovation Solution

A condenser with a built-in filter heating system using a vortex tube to provide both cooling and heating, where a cold gas stream is conveyed through a cooling conduit and a hot gas stream through a heating conduit, integrated with a bioreactor exhaust system to manage moisture effectively.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a separate filter heater is added to prevent condensation, then condensation is prevented, but device complexity increases

Engineering Contradiction:
Improvecondensation preventionVSAvoidsystem complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines the filter heater function with the condenser housing into a single integrated unit. The heater element is positioned within the condenser assembly, allowing simultaneous condensation of moisture and heating of the filter to prevent condensation on the filter surface, thereby eliminating the need for a separate filter heater device.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The condenser assembly is designed to perform multiple functions: condensing moisture from the gas stream, housing the filter, and providing heating to the filter. This multi-functional design consolidates what would traditionally require separate components into a single versatile unit, reducing overall system complexity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Loss of substance

If cooling is applied to condense moisture, then moisture is removed, but filter temperature may drop causing condensation on filter

Engineering Contradiction:
Improvemoisture removalVSAvoidfilter condensation prevention
Core Design Contradiction:
Loss of substanceVSReliability

Solution Approach 1:

The condenser and filter heater are integrated into a single assembly where the cooling conduit for condensing moisture and the heating element for the filter work together in close proximity. This allows the system to simultaneously cool the gas stream for condensation while maintaining filter temperature above the dew point, preventing filter condensation.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The integrated design uses the condenser housing as an intermediary structure that separates the cooling function (condensing moisture from gas) from the filter, while the heating element acts as a mediator to maintain filter temperature. This intermediary structure allows independent control of cooling and heating functions within the same assembly.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This integrated solution simplifies the system, effectively prevents condensation, and recycles condensate back to the bioreactor, maintaining optimal gas concentrations and extending filter lifespan.

Implementation Method 1

a vortex tube arranged to convey a cold gas stream through the cooling conduit and to convey a hot gas stream through the heating conduit

Methodology Applied
Scientific EffectRanque-Hilsch effect: Ranque-Hilsch Effect

Implementation Method 2

The moisture in the gas may condense as the gas passes through a filter or other system component

Methodology Applied
Scientific EffectCondensation: Condensation

Data Source

PatentEP3341099B1Bioreactor condenser
Publication Date: 2019.01.09 GE HEALTHCARE BIO SCIENCES AB
  • EP3341099B1 patent drawingFigure 1
  • EP3341099B1 patent drawingFigure 2
  • EP3341099B1 patent drawingFigure 3

AI summary

The invention discloses a condenser for a bioreactor exhaust, comprising: an inlet (1) adapted to be fluidically connected to a bioreactor exhaust port (2), a cooling chamber (3; 103) fluidically connected to the inlet and via a filter device (4) to an outlet (5), a cooling conduit (6; 106) in contact with the cooling chamber, a heating conduit (7) in contact with the filter device and a vortex tube (8) arranged to convey a cold gas stream through the cooling conduit and to convey a hot gas stream through the heating conduit.