Bioreactor Chamber With Cyclic Support Deformation for Tissue Maturation

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Solution Overview

Problem

Existing bioreactor chambers for growing and maturing tissues lack precise control over mechanical stimulation, leading to inadequate induction of vital functions in cells, particularly for tissues like heart and lung.

Innovation Solution

A bioreactor chamber with a flexible support that is permeable to culture medium, subjected to cyclical movement by a pressure surface that intermittently contacts the support, allowing precise control over deformation and simulating physiological conditions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If continuous mechanical stimulation is applied to the support, then cell vitality induction is improved, but control precision over deformation is reduced

Engineering Contradiction:

Improvecell vitality inductionVSAvoiddeformation control precision

Core Design Contradiction:

ReliabilityVSMeasurement precision

Solution Approach 1:

The patent applies periodic action by using a pressure surface that intermittently contacts the flexible support to generate cyclical movement. This periodic mechanical stimulation induces vital functions in cells while allowing precise control over the deformation applied to the support, resolving the contradiction between stimulation effectiveness and control precision.

Inventive Principle:

Principle #19Periodic action

2Reliability

If mechanical stimulation means are added to the bioreactor chamber, then cell function induction is improved, but device complexity increases

Engineering Contradiction:

Improvecell function inductionVSAvoidchamber structure complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The pressure surface serves multiple functions: it provides mechanical stimulation to induce cell vitality, generates cyclical movement of the support, and maintains structural integration with the chamber. This multi-functionality reduces overall device complexity while achieving reliable cell function induction.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances the induction of vital functions in cells by precisely controlling deformation, reducing the risk of tissue necrosis and improving the structural and functional characteristics of tissues like heart muscle, facilitating successful implantation.

Implementation Method 1

mechanical stimulation means which generate a cyclical movement of the support by means of a pressure surface which pushes the support by intermittently contacting said support

Methodology Applied

Scientific EffectMechanical Force: Mechanical Force

Implementation Method 2

a flexible support that is permeable to the culture medium in which cells that will form the tissue are arranged

Methodology Applied

Scientific EffectElasticity: Elasticity

Data Source

PatentEP4644528A1Bioreactor chamber for growing and/or maturing a tissue and method for growing and/or maturing a tissue in a bioreactor chamber

Publication Date: 2025.11.05 LEARTIKER SCOOP

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AI summary

Bioreactor chamber for growing and/or maturing a tissue comprising a container (1) for containing a culture medium and securing means (2) configured to secure inside the container a flexible support (S) that is permeable to the culture medium in which cells that will form the tissue are arranged. The chamber further comprises mechanical stimulation means (3) which generate a cyclical movement of the support (S) by means of a pressure surface (4) which pushes the support (S) by intermittently contacting said support (S). Method for growing and/or maturing a tissue in a bioreactor chamber.