Bioreactor Effluent NMR Monitoring With Uniform Magnet Fields
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Solution Overview
Problem
Current desktop NMR devices are heavy and costly, limiting their application in production settings, and they lack the capability to analyze multiple samples simultaneously for rapid tissue analysis.
Innovation Solution
The system employs magnet configurations with rotatable and laterally movable magnets, combined with magnetic field spreaders, to create a stable magnetic field for reliable measurements. This setup includes a rotatable magnet, a second magnet positioned to form a magnetic field across the effluent, and an adjustment mechanism to rotate the rotatable magnet, ensuring a uniform magnetic field for characterization of tissue samples.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional desktop NMR devices are used, then measurement precision is maintained, but device weight and cost increase significantly
Solution Approach 1:
The patent extracts the essential NMR measurement function from the heavy traditional desktop device architecture. By using a portable magnet configuration with effluent flowing through a tube positioned between magnetic poles, the system separates the core measurement capability from the bulky equipment, achieving accurate NMR measurements in a lightweight portable format suitable for production environments
Solution Approach 2:
The patent employs cost-effective permanent magnets and simple mechanical positioning components instead of expensive electromagnets and complex control systems. The effluent analysis system uses disposable or reusable sample containers that flow through the magnetic field, eliminating the need for expensive specialized NMR sample holders and reducing overall system cost
2Measurement precision
If traditional NMR devices are used, then measurement capability is maintained, but device cost increases
Solution Approach 1:
The patent uses inexpensive permanent magnets and simple mechanical components to create a cost-effective NMR system. The effluent analysis setup employs basic tube and container configurations rather than expensive specialized NMR equipment, making the technology economically viable for production settings
Solution Approach 2:
The patent extracts the essential measurement function from expensive traditional NMR devices and implements it using simple, low-cost components. By focusing only on the core NMR measurement capability and eliminating unnecessary expensive features, the system achieves measurement capability at a fraction of the traditional cost
3Measurement precision
If single-sample analysis is performed, then measurement precision is maintained, but productivity decreases
Solution Approach 1:
The patent implements continuous effluent flow through the NMR measurement zone, allowing uninterrupted analysis. The system maintains constant flow of bioreactor effluent through the tube between magnetic poles, enabling continuous monitoring without discrete sampling interruptions, thereby maintaining both measurement precision and high productivity
Solution Approach 2:
The patent positions the effluent flow path and magnetic field configuration in advance to enable immediate analysis upon effluent generation. The system is pre-configured with the tube, magnets, and detection equipment aligned so that effluent can be analyzed continuously as it flows, eliminating preparation time between samples
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enables efficient and cost-effective characterization of tissue samples by providing a stable and uniform magnetic field, allowing for reliable identification of effluent contents and rapid tissue analysis, even in production settings.
Implementation Method 1
a second magnet positioned in proximity to the at least one container. The second magnet can be positioned to form a magnetic field across the effluent
Implementation Method 2
Nuclear magnetic resonance (NMR) involves applying a magnetic field to the material, and the composition of the material determines the frequency of the resonance. When resonance is achieved, the material is illuminated for a short time with a radio frequency (RF) signal at the frequency of the resonance
Implementation Method 3
When the material is illuminated, the material absorbs some of the signal's energy. When there is no illumination, the material will echo some of the absorbed energy back out. The echo can be used to identify the material
Implementation Method 4
Magnet positioning, in conjunction with magnetic field spreaders, can provide a stable magnetic field from which reliable measurements can be taken
Data Source
AI summary
A magnetic resonance device for monitoring growth of tissue in one or more bioreactors. The device can include a first magnet and a second magnet that can form a uniform magnetic field of desired strength around at least one sample of effluent from at least one bioreactor. At the command of a controller, an RF signal can illuminate the at least one magnetized sample, and sensors can detect at least one echo signal from the at least one magnetized sample. The controller can characterize the at least one sample based on the at least one echo signal. A resonator can shape the at least one echo signal.