Bioreactor Recipe Control With Centralized Version Locking
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Solution Overview
Problem
In biomanufacturing, different users editing recipes in different data stores can lead to conflicting instructions for bioreactors, resulting in disparate and conflicting control parameters, which complicates the automation and consistency of biomanufacturing processes.
Innovation Solution
A client-facing data assimilation system that allows credentialed users to create, monitor, and alter recipes centrally, ensuring only one version of the recipe is edited at a time, with real-time monitoring and control of bioreactors, and integration with cloud-based data storage to manage recipe updates and bioreactor operations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If multiple users edit recipes in different data stores simultaneously, then user flexibility and autonomy are improved, but recipe consistency and control reliability deteriorate due to conflicting instructions
Solution Approach 1:
The patent introduces a central data store as an intermediary between multiple users and the bioreactor control system. This central repository mediates all recipe edits, ensuring that only one version of each recipe exists at any given time. The system allows users to submit edits through this intermediary, which then manages version control and distribution, preventing conflicting instructions while maintaining user flexibility.
Solution Approach 2:
The patent merges multiple distributed data stores into a single centralized data store for recipe management. By combining what were previously separate recipe repositories into one unified system, the patent eliminates the possibility of conflicting recipe versions while still allowing multiple users to access and edit recipes through a common interface.
2Manufacturing precision
If manual handling and individualized attention are used for seed preparation and sample analysis, then process accuracy is improved, but productivity and throughput deteriorate
Solution Approach 1:
The patent implements automated systems that perform seed preparation and sample analysis without requiring continuous manual intervention. The bioreactor system automatically executes recipes, performs sampling, and conducts analyses, allowing the system to serve itself while maintaining high accuracy standards. This automation enables the system to handle multiple experiments simultaneously, dramatically increasing throughput.
Solution Approach 2:
The patent replaces manual mechanical operations with automated mechanical and computational systems. Automated dispensing systems, robotic sample handlers, and computer-controlled analysis instruments substitute for manual handling, maintaining precision while enabling high-throughput operation of multiple bioreactors simultaneously.
3Adaptability or versatility
If recipes are frequently edited to accommodate user desires, then adaptability is improved, but system complexity and potential for errors increase
Solution Approach 1:
The patent implements a feedback mechanism where the central data store continuously monitors and tracks all recipe edits. When a user modifies a recipe, the system provides feedback about the changes, validates them against existing parameters, and automatically updates the centralized repository. This feedback loop maintains adaptability while preventing errors through systematic validation and version control.
Solution Approach 2:
The patent creates a dynamic recipe management system where recipes can be easily modified through a standardized interface. The system adapts to user needs by allowing frequent edits while maintaining order through automated version control, change tracking, and centralized storage that dynamically updates all connected bioreactors.
Data Source
AI summary
Systems and methods described herein provide a data presentation, assimilation and monitoring system for a biomanufacturing system utilizing an array of bioreactors for conducting biomanufacturing experiments. In embodiments, the experiments may be controlled by recipes that can be created and altered by credentialed users. During experiments, credentialled users may monitor operational parameters of the bioreactors conducting experiments as well as batch and group parameters across multiple bioreactors. Further, credentialled users may alter recipes to the exclusion of other credentialled users while editing. Further yet, specific checklists may be utilized to ensure that correct and suited equipment (such as bioreactors and experiment bays) are matched with an experiment plan.