Bioreactor Rotary Scoop Chamber for Hollow Organ Flushing
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Solution Overview
Problem
Existing bioreactors face challenges in effectively flushing the interior of hollow organs during liquid exchange, requiring additional pumps which increase complexity and cost.
Innovation Solution
A bioreactor design featuring a rotary device with a scoop chamber and flow duct system that rotates a hollow organ within a liquid-filled housing, allowing liquid to enter and circulate through the organ's interior via a rotatable member, ensuring efficient internal flushing without the need for additional pumps.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If an additional electric or hydraulic pump is used to flush the interior of the hollow organ, then the liquid exchange in the interior is improved, but the device complexity and cost increase
Solution Approach 1:
The patent extracts the flushing function from a separate pump system and integrates it into the rotary device itself. The rotatable holding member with its scoop chamber and flow duct performs the flushing action through rotational motion, eliminating the need for additional electric or hydraulic pumps while maintaining effective liquid exchange in the hollow organ's interior
Solution Approach 2:
The rotary device serves dual purposes: it rotates the hollow organ for external liquid exposure and simultaneously performs internal flushing through its integrated flow duct system. The rotational motion itself generates the flushing action, making the system self-sufficient without requiring separate pumping mechanisms
2Ease of operation
If the hollow organ is rotated in the liquid, then the outside of the organ is exposed to liquid, but the interior flushing becomes insufficient
Solution Approach 1:
The patent segments the liquid delivery system into two distinct pathways: one for external exposure (the housing liquid environment) and one for internal flushing (the flow duct connected to the scoop chamber). This segmentation allows both functions to occur simultaneously without interfering with each other, ensuring adequate interior flushing while maintaining simple external liquid exposure
Solution Approach 2:
The patent adds a dimensional aspect to liquid delivery by using the rotational dimension of the rotary device to drive liquid through the flow duct into the hollow organ's interior. The rotational motion creates a dynamic flushing mechanism that complements the static external liquid exposure, ensuring thorough interior liquid exchange
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This design simplifies and cost-effectively ensures thorough liquid exchange within hollow organs, preventing cell clumping and maintaining sterility, while allowing for continuous supply of fresh liquid and cells.
Implementation Method 1
a rotary device that is arranged in the housing and is configured for rotating a hollow organ or organ scaffold about a longitudinal axis in a region of the liquid level
Data Source
AI summary
The invention relates to a bioreactor for charging the outside and the interior of a hollow element (1) or hollow element framework with a liquid, having a housing (2) accommodating the liquid, forming a liquid surface, and a rotation device (3) arranged within the housing (2) and receiving the hollow element (1), which rotation device (3) is for rotating the hollow element (1) about the longitudinal axis (4) thereof in the region of the liquid surface. In known bioreactors of this type, the interior of the hollow element must be flushed with a special device, and so here also a liquid exchange takes place. The object of forming a bioreactor for charging the interior and the outside of hollow elements in such a manner that simplest and cheapest flushing of the interior of the hollow element is ensured is achieved in that the rotation device (3) comprises a scooping chamber (5) running at least in part tangentially to the longitudinal axis, and which is connected via a flow channel (6) to the interior of the hollow element (1).