Bioreactor Temperature Sensor Thermal Insulation

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Solution Overview

Problem

Existing bioreactor temperature sensors are affected by ambient temperature, leading to unreliable measurements and requiring calibration of the tray holding the bioreactor, which complicates handling and accuracy.

Innovation Solution

A bioreactor system with temperature sensors integrated into the base station, featuring a thermally conducting layer facing the surface, a thermally insulating layer surrounding the sensor, and a control system for ambient temperature compensation, minimizing ambient temperature influence and eliminating the need for tray calibration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If temperature sensors are provided outside the bioreactor, then noninvasive measurement is achieved, but ambient temperature affects the measured temperature

Engineering Contradiction:
Improvemeasurement reliabilityVSAvoidambient temperature influence
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

A thermally insulating layer is introduced as an intermediary between the temperature sensor and the ambient environment. This layer acts as a thermal barrier that blocks heat transfer from the surroundings to the sensor, allowing the sensor to accurately measure bioreactor temperature without direct thermal coupling to ambient conditions.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The temperature measurement system is segmented into distinct functional layers: a thermally conducting layer that couples the sensor to the bioreactor, a thermally insulating layer that isolates the sensor from ambient temperature, and the sensor itself. This segmentation allows each layer to perform its specific thermal function independently.

Inventive Principle:
Principle #1Segmentation

2Measurement precision

If temperature sensors are integrated into the base station with thermal insulation, then ambient temperature influence is minimized, but device complexity increases

Engineering Contradiction:
Improvetemperature measurement accuracyVSAvoidsensor structure complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The thermal insulation is implemented using thin film layers that can be integrated into the base station structure. These thin thermal management layers provide effective insulation without adding significant bulk or complexity to the device, maintaining a compact and simple overall design while achieving precise temperature measurements.

Inventive Principle:
Principle #30Flexible shells and thin films

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This configuration provides reliable temperature measurements with minimal ambient temperature interference and simplifies handling by isolating the calibration process to the base station, ensuring accurate and convenient operation.

Implementation Method 1

a thermally conducting layer (2) arranged to face the surface to be measured

Methodology Applied
Scientific EffectThermal conduction: Conduction (thermal)

Implementation Method 2

a thermally insulating layer (3) attached to the thermally conducting layer (2) on the opposite side to the surface to be measured

Methodology Applied
Scientific EffectThermal insulation: Thermal Insulation

Data Source

PatentEP3011290B1Bioreactor system comprising a temperature sensor means
Publication Date: 2020.05.13 CYTIVA SWEDEN AB
  • EP3011290B1 patent drawingFigure 1~2b
  • EP3011290B1 patent drawingFigure 3~4b

AI summary

A temperature sensor means (1) comprising a thermally conducting layer (2) arranged to face the surface to be measured,a thermally insulating layer (3) attached to the thermally conducting layer (2) on the opposite side to the surface to be measured, a temperature sensor (5) provided between the thermally conducting layer (2) and the thermally insulating layer (3) and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.