Bioresorbable Extracellular Matrix Hemostatic Device

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Solution Overview

Problem

Current topical hemostatic agents fail to achieve rapid, effective, and bioresorbable hemostasis with minimal tissue reaction, lack antimicrobial properties, and are not suitable for internal use, leading to uncontrolled hemorrhage in traumatic injuries.

Innovation Solution

A bioresorbable hemostatic device made from compressed, dehydrated extracellular matrix material derived from epithelial tissue, specifically urinary bladder matrix, which includes epithelial basement membrane and other layers, providing rapid hemostasis, antimicrobial properties, and ease of application both internally and externally.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If thermal coagulation is used to achieve hemostasis, then bleeding is stopped, but thermal damage occurs to surrounding tissues

Engineering Contradiction:

Improvehemostasis effectivenessVSAvoidthermal damage to tissues

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces thermal coagulation (thermal energy-based system) with a mechanical/physical system using compressed extracellular matrix material that achieves hemostasis through absorption, compression, and biological compatibility rather than thermal energy, thereby eliminating thermal damage to surrounding tissues

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If current topical hemostatic agents are used, then hemostasis is achieved, but they lack antimicrobial properties and are not suitable for internal use

Engineering Contradiction:

Improvehemostasis effectivenessVSAvoidsuitability for internal and external use with antimicrobial properties

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent creates a universal hemostatic device from extracellular matrix material that simultaneously provides hemostasis, antimicrobial protection, and biocompatibility for both internal and external use, replacing multiple specialized agents with a single multi-functional material

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent modifies the physical and chemical parameters of the extracellular matrix material through compression and dehydration to achieve the desired balance of hemostatic effectiveness, antimicrobial properties, and biocompatibility for versatile application

Inventive Principle:

Principle #35Parameter changes

3Reliability

If non-bioabsorbable hemostatic dressings are used, then hemostasis is achieved, but they remain in the body indefinitely causing potential complications

Engineering Contradiction:

Improvehemostasis effectivenessVSAvoidpresence duration in body

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent employs a bioabsorbable material that performs its hemostatic function and then gradually degrades and is absorbed by the body, eliminating the need for removal and avoiding long-term presence complications while maintaining effective hemostasis during the critical period

Inventive Principle:

Principle #34Discarding and recovering

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device induces rapid hemostasis, is bioresorbable, minimally reactive with tissues, and has antimicrobial properties, making it suitable for both external and internal use, while serving as a tissue regenerative scaffold for wound repair.

Implementation Method 1

The device induces rapid hemostasis

Methodology Applied

Scientific EffectAbsorption: Absorption (physical)

Implementation Method 2

compressed, dehydrated extracellular matrix material

Methodology Applied

Scientific EffectCapillary action: Capillary Action

Data Source

PatentUS9404077B2Hemostatic device

Publication Date: 2016.08.02 ACELL INC

AI summary

A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce hemostasis at an anatomical site.