Biosensing Test Strip Exhaust Flow Control for Uniform Mixing
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Solution Overview
Problem
Existing test strips for in vitro medical measurements face challenges in controlling the flow of liquid samples due to capillary forces, leading to non-uniform mixing and potential damage to samples, especially when multiple agents are involved, and external power devices require precise bonding and can cause sample damage.
Innovation Solution
A biosensor strip with an exhaust flow channel configured to reduce liquid sample flow, utilizing resistance parameters to control the flow through a biosensor strip structure, including a reaction flow channel, separation layer, and exhaust flow channel, with through holes for communication, and optionally incorporating hydrophilic layers and choke valves to manage flow.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If capillary force is used to absorb liquid sample into reaction zone, then the test strip structure is simple, but the flow and force of liquid sample cannot be controlled leading to non-uniform mixing
Solution Approach 1:
The patent introduces an exhaust flow channel with adjustable resistance parameters to control the flow rate of liquid sample. By changing the resistance parameter of the exhaust flow channel, the flow rate can be precisely controlled, ensuring uniform mixing of multiple agents while maintaining a relatively simple test strip structure.
Solution Approach 2:
The exhaust flow channel acts as an intermediary component between the reaction flow channel and the external environment. It mediates the flow control by providing a controlled exhaust path that regulates the liquid sample flow rate through its resistance characteristics, enabling precise flow control without complex external devices.
2Manufacturing precision
If external power device is used to control flow, then flow control is achieved, but sample damage occurs and high-precision bonding is required
Solution Approach 1:
The test strip uses its own internal exhaust flow channel structure to achieve flow control without requiring external power devices. The exhaust flow channel's resistance characteristics enable the system to self-regulate the liquid sample flow rate, eliminating the need for external pumps or pressure devices that could damage samples or require precise bonding.
3Manufacturing precision
If exhaust flow channel is added to control flow, then flow rate control is improved, but device complexity increases
Solution Approach 1:
The exhaust flow channel is integrated into the test strip structure by merging it with the reaction flow channel through a through-hole in the separation layer. This combining approach allows flow control functionality to be added without significantly increasing overall device complexity, as the exhaust channel shares structural elements with the reaction channel.
Solution Approach 2:
The exhaust flow channel serves multiple functions: it controls the flow rate of liquid sample, provides a path for gas exhaust, and works in conjunction with the reaction flow channel to ensure uniform mixing. This multi-functionality reduces the need for additional separate components, thereby limiting the increase in device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biosensor strip effectively controls the flow of liquid samples, ensuring uniform mixing and reducing the risk of sample damage, while allowing for precise control of reaction times and flow rates, enhancing the reliability of biochemical tests.
Implementation Method 1
the exhaust flow channel that is configured to reduce the flow of a liquid sample provided by a capillary action
Data Source
AI summary
Disclosed are a biosensing test strip (100, 200, 300, 500, 600, 700, 800, 900, 1000, 1100) and a biosensing test method. The biosensing test strip (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100) comprises: a reaction layer (120, 220, 720, 820) provided with a reaction flow channel (121, 221, 821, 920, 1020); a partition plate layer (130, 230) located above the reaction layer (120, 220, 720, 820) and covering the reaction flow channel (121, 221, 821, 920, 1020); an exhaust layer (140, 240, 540, 640) located above the partition plate layer (130, 230), with the exhaust layer (140, 240, 540, 640) being provided with an exhaust flow channel (141, 241, 550, 650); and a communication hole passing through the partition plate layer (130, 230) to enable the exhaust flow channel (141, 241, 550, 650) to be in communication with the reaction flow channel (121, 221, 821, 920, 1020).