Magnetic Biosensor Ultrasonic Standing Wave Signal Detection
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Solution Overview
Problem
Current magnetic biosensing methods face challenges in detecting trace biomolecules due to non-selective spreading of biomolecules and magnetic beads, leading to reduced stray fields and weak sensing signals, as the magnetic beads' positions result in offsetting induced fields.
Innovation Solution
A magnetic biosensor system incorporating a fluidic channel and an acoustic wave emitter that generates an ultrasonic standing wave, guiding biomolecules to specific node positions where magnetic sensors can effectively detect bonded magnetic components, enhancing the magnetic induction signal by positioning magnetic components for optimal stray field detection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If magnetic beads are non-selectively spread on the biosensor, then the biosensor can detect biomolecules, but the induced stray fields from magnetic beads at different positions offset each other, reducing the total induced stray field and weakening the sensing signal
Solution Approach 1:
The patent applies preliminary action by using acoustic waves to pre-position magnetic beads at specific locations on the biosensor surface before detection. The acoustic wave emitter generates standing waves that create acoustic radiation pressure, forcing magnetic beads to accumulate at nodal points where the acoustic energy is minimal. This pre-positioning ensures that all magnetic beads contribute constructively to the magnetic signal rather than canceling each other out through random distribution.
Solution Approach 2:
The patent implements local quality by creating regions of high magnetic bead concentration at specific nodal positions rather than uniform distribution. The acoustic standing wave pattern creates distinct local zones (nodes) where magnetic beads are concentrated, while other regions (antinodes) remain relatively empty. This localized concentration optimizes the magnetic signal at detection points while maintaining the ability to detect biomolecules throughout the sensor surface.
2Area of stationary object
If magnetic beads are positioned at different locations on the biosensor, then the biosensor can cover a larger detection area, but the induced stray fields from magnetic beads generate opposite directions that offset each other, reducing the total induced stray field
Solution Approach 1:
The acoustic wave emitter pre-positions magnetic beads at specific nodal locations across the detection area before biomolecule binding occurs. This preliminary positioning ensures that regardless of the detection area size, all magnetic beads are strategically placed at locations where their magnetic fields will be detected with maximum efficiency and will not cancel each other out.
Solution Approach 2:
The patent introduces acoustic wave dimensionality to control magnetic bead positioning. By using acoustic standing waves with specific wavelengths, the system creates a three-dimensional acoustic field that manifests as two-dimensional nodal patterns on the sensor surface. This allows precise spatial control of magnetic bead positions across the detection area, enabling large-area detection while maintaining optimal magnetic field orientation and strength at each location.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration allows for the detection of trace biomolecules by concentrating magnetic components at predetermined locations, preventing field cancellation and enhancing the intensity of the magnetic induction signal, thereby improving the sensitivity of the biosensor for trace biomolecule detection.
Implementation Method 1
generating an ultrasonic standing wave, and driving the plurality of biomolecules to a node position of the ultrasonic standing wave
Implementation Method 2
sensing the plurality of magnetic components through the magnetic sensor, to obtain a magnetic induction signal
Data Source
AI summary
A magnetic biosensor includes a fluidic channel, a magnetic sensor and an acoustic wave emitter. The disposition of the magnetic sensor corresponds to the fluidic channel. The acoustic wave emitter includes two wave generating units, and the fluidic channel is disposed between the two wave generating units.


