Biosensor Analyte Concentration Compensation via Anchor Parameters
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Solution Overview
Problem
Biosensor systems face challenges in accurately determining analyte concentrations due to errors introduced by both the measurement device and output signals, which are difficult to compensate for, especially those related to system errors and physical characteristics of the sample.
Innovation Solution
A biosensor system with a processor that measures multiple analyte responsive output signals, determines initial analyte concentrations, and uses anchor parameters to compensate for system errors through progressive approximation of pseudo-reference concentrations, thereby improving measurement performance by reducing total error.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple output signals are measured and anchor parameters are used to compensate for system errors, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The system performs preliminary measurements of multiple output signals (including extraneous stimulus signals) and pre-calculates anchor parameters based on these measurements. By determining anchor parameters from actual sample measurements rather than relying solely on pre-stored calibration data, the system adapts to specific sample conditions and compensates for system errors more effectively, improving measurement precision without requiring complex real-time computations during the actual analyte concentration determination
Solution Approach 2:
The patent introduces anchor parameters as intermediary values that mediate between the raw output signals and the final analyte concentration calculation. These anchor parameters serve as correction factors that account for system errors and extraneous stimuli, allowing the system to compensate for measurement errors without directly modifying the core measurement algorithm or requiring complex computational models
2Reliability
If anchor parameters are determined using pseudo-reference concentrations, then reliability of error compensation is improved, but measurement precision temporarily deteriorates
Solution Approach 1:
The system implements an iterative process where anchor parameters are determined using pseudo-reference concentrations, applied to compensate errors, then re-evaluated with improved measurements. This periodic refinement cycle allows the system to progressively improve measurement precision while maintaining reliable error compensation through the anchor parameter framework. The iterative approach enables the system to converge toward more accurate results without requiring perfect initial measurements
Solution Approach 2:
The patent employs dynamic adjustment of anchor parameters based on actual sample measurements rather than using fixed, pre-determined values. The system adapts the anchor parameters to match the specific conditions of each sample being analyzed, allowing the error compensation mechanism to remain reliable across varying sample conditions while improving measurement precision through adaptive optimization
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system achieves enhanced accuracy and precision in analyte concentration determination by effectively compensating for both system and output signal errors, leading to improved measurement performance and reduced variability in results.
Implementation Method 1
A chemical indicator such as tetrazolium along with an enzyme such as diaphorase may be used. Tetrazolium usually forms formazan (a chromagen) in response to the redox reaction of the analyte. An incident input beam from a light source is directed toward the sample. The light source may be a laser, a light emitting diode, or the like. The incident beam may have a wavelength selected for absorption by the reaction product. As the incident beam passes through the sample, the reaction product absorbs a portion of the incident beam, thus attenuating or reducing the intensity of the incident beam.
Implementation Method 2
The incident beam may be reflected back from or transmitted through the sample to a detector. The detector collects and measures the attenuated incident beam (output signal).
Implementation Method 3
In light-generated optical systems, the chemical indicator fluoresces or emits light in response to the analyte when illuminated by an excitation beam.
Implementation Method 4
A chemical indicator such as tetrazolium along with an enzyme such as diaphorase may be used. Tetrazolium usually forms formazan (a chromagen) in response to the redox reaction of the analyte.
Implementation Method 5
In either optical system, the system measures and correlates the light with the analyte concentration of the sample. The amount of light attenuated by the reaction product is an indication of the analyte concentration in the sample.
Data Source
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AI summary
The application relates to an analyte measurement device, comprising: electrical circuitry connected to a sensor interface, wherein the electrical circuitry includes a processor connected to a signal generator and a storage medium; wherein the processor is capable of measuring at least two analyte responsive output signals from the sample; wherein the processor is capable of determining at least two initial analyte concentrations from the at least two analyte responsive output signals; wherein the processor is capable of determining a first pseudo-reference concentration from the at least two analyte responsive output signals, wherein the first pseudo-reference concentration is a first substitute for true relative error; wherein the processor is capable of determining at least one first anchor parameter in response to the first pseudo-reference concentration, wherein the at least one first anchor parameter compensates for system error; wherein the processor is capable of incorporating the at least one first anchor parameter into at least two first compensation relationships; wherein the processor is capable of determining at least two first anchor compensated analyte concentrations in response to the at least two initial analyte concentrations, the at least two first anchor parameters, and the at least two first compensation relationships; wherein the processor is capable of determining a second pseudo-reference concentration by averaging the at least two first anchor compensated analyte concentrations, wherein the second pseudo-reference concentration is a second substitute for true relative error; and wherein the processor is capable of reporting the second pseudo-reference concentration as a final compensated analyte concentration of the sample.