Biosensor Array Self-Calibration via Back Gate Voltage Adjustment
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Solution Overview
Problem
Biosensors in arrays often exhibit varying sensing characteristics, leading to inconsistent output currents when measuring pH values, which complicates their application in real-world scenarios where uniform responses are desired.
Innovation Solution
A self-calibration method and circuit are introduced, utilizing a decision unit and correction factor generator to adjust back gate voltages across biosensors in an array, ensuring uniform output currents by comparing and adjusting individual biosensor responses relative to a reference, thereby achieving consistent pH sensing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If biosensors are manufactured in arrays with high integration density, then productivity and integration density are improved, but manufacturing precision and uniformity of sensing characteristics deteriorate
Solution Approach 1:
The patent applies parameter changes by adjusting the back gate voltage of each biosensor individually through digital-to-analog conversion. This allows modification of the electrical parameters of each sensor to compensate for manufacturing variations, achieving uniform sensing characteristics across the array without requiring perfect manufacturing precision.
Solution Approach 2:
The patent implements feedback by measuring the output current of each biosensor and using this information to calculate correction factors. These correction factors are then applied to adjust the back gate voltage, creating a closed-loop system that automatically compensates for manufacturing variations and achieves uniform response across all sensors.
2Measurement precision
If individual biosensor adjustments are made to achieve uniform responses, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The patent applies universality by using a single calibration circuit architecture that can calibrate multiple biosensors through multiplexing. The same digital-to-analog converter and control logic are reused for each sensor, reducing the need for separate calibration circuits for each biosensor and thereby limiting the increase in device complexity.
Solution Approach 2:
The patent implements self-service by enabling the biosensor array to perform its own calibration automatically. The system measures its own output currents, calculates correction factors, and adjusts its own back gate voltages without requiring external calibration equipment or manual intervention, thereby managing the complexity internally.
Data Source
AI summary
A device includes a first biosensor of a biosensor array; a second biosensor of a biosensor array; a readout circuit electrically connected to the biosensor array; a decoder electrically connected to the biosensor array; a voltage generator electrically connected to the biosensor array; and a decision system electrically connected to the voltage generator and the readout circuit.