Biosensor Capillary Chip Segmentation for Portability and Precision
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional biosensors require complex analysis processes, specialized knowledge, and laboratory equipment, making them inconvenient and difficult for widespread use due to low reproducibility and accuracy, especially in strip schemes.
Innovation Solution
A portable one-touch biosensor system featuring a capillary chip with chromogenic enzyme-detection antibodies and capture antibodies for antigen-antibody reactions, coupled with a photo sensor for color detection, and a pre-treatment part for easy substrate delivery, enhancing accuracy and reproducibility through a simplified ELISA method.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If conventional ELISA methods are used, then comprehensive analysis capability is achieved, but device complexity and operational difficulty increase
Solution Approach 1:
The biosensor is divided into distinct functional modules: a sensor part containing a capillary chip with antibody-coated regions for antigen capture and detection, and a pre-treatment part that prepares and delivers the sample. This segmentation allows each module to perform its specific function independently, simplifying the overall system while maintaining comprehensive analysis capability.
Solution Approach 2:
The capillary chip is inserted into the pre-treatment part, creating a nested structure where the sensor part is housed within the pre-treatment part. This nested design integrates multiple functions into a compact unit, reducing device complexity while preserving the complete ELISA workflow capability.
2Device complexity
If strip scheme biosensors are used, then portability is improved, but measurement precision and reliability deteriorate
Solution Approach 1:
The biosensor separates the sample preparation function (pre-treatment part) from the detection function (sensor part with capillary chip). This segmentation allows the detection portion to be compact and portable while maintaining precise measurement capabilities through controlled antigen-antibody reactions within the capillary structure.
Solution Approach 2:
The capillary chip features localized antibody coatings in specific regions to capture target antigens with high precision. The pre-treatment part provides a controlled environment for sample preparation, ensuring consistent and reliable measurements. This localized functional distribution maintains measurement precision while enabling portability.
3Measurement precision
If professional knowledge is required for operation, then measurement accuracy is maintained, but ease of operation decreases
Solution Approach 1:
The pre-treatment part automatically performs sample preparation and delivery to the sensor part without requiring user intervention for complex procedures. The capillary chip self-contained structure ensures proper reagent mixing and antigen capture, eliminating the need for specialized knowledge while maintaining measurement accuracy.
Solution Approach 2:
The pre-treatment part performs all necessary sample preparation actions in advance before the sample reaches the detection region. This preliminary processing includes mixing, incubation, and delivery, so that when the sample enters the capillary chip, the detection can proceed automatically with high accuracy without requiring user expertise.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biosensor system provides improved accuracy and reproducibility, enabling easy, efficient detection of target materials with a user-friendly interface, suitable for point-of-care diagnostics and field applications.
Implementation Method 1
a chromogenic enzyme-detection antibody provided onto an inner wall of the capillary in the first region
Implementation Method 2
a photo sensor detecting whether the substrate develops a color
Implementation Method 3
a capillary chip configured to detect a target material; and a pre-treatment part connected to the sensor part and configured to provide a mixed solution including a substrate to the sensor part
Implementation Method 4
at least one of antibody for antigen-antibody reaction with the target material inside the capillary
Data Source
AI summary
Disclosed is a biosensor, comprising: a sensor part including a capillary chip configured to detect a target material; and a pre-treatment part connected to the sensor part and configured to provide a mixed solution including a substrate to the sensor part, in which the capillary chip includes a capillary, at least one of antibody for antigen-antibody reaction with the target material inside the capillary, and a photo sensor detecting a color of the substrate.