Biosensor Capillary Vent Slit Design for Rapid Sample Introduction
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Solution Overview
Problem
Conventional biosensors face challenges in introducing samples into capillary gaps at high speeds due to complex and costly manufacturing processes, slow sample introduction caused by air discharge through vent holes, and friction against capillary walls.
Innovation Solution
A biosensor design featuring a first substrate with a recess and a second substrate with reaction and delivery electrodes, where the second substrate is attached to form a capillary structure with vent slits, allowing air to be discharged quickly and reducing friction, thus enabling faster sample introduction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If conventional capillary structures with vent holes are used to introduce samples, then air can be discharged to enable sample introduction, but the sample introduction speed is low and the manufacturing process is complicated
Solution Approach 1:
The capillary wall is segmented into multiple vent slits instead of using a single vent hole or complex multi-substrate structure. This segmentation simplifies the manufacturing process while increasing the total venting area, allowing faster air discharge and higher sample introduction speed.
Solution Approach 2:
The vent slits are formed by combining the recess in the first substrate with the edge surface of the second substrate, creating a three-dimensional venting structure that simplifies manufacturing compared to conventional two-substrate capillary formations while improving sample introduction efficiency.
2Speed
If conventional vent holes are used for air discharge, then sample introduction is enabled, but air discharge speed is limited and sample introduction remains slow
Solution Approach 1:
The single vent hole is segmented into multiple vent slits distributed along the capillary structure. This increases the total venting area and allows parallel air discharge through multiple pathways, significantly improving air discharge speed and overall sample introduction efficiency.
Solution Approach 2:
Vent slits are strategically positioned at specific locations where air accumulation most significantly impedes sample flow. This localized optimization of venting positions maximizes air discharge efficiency without requiring uniform distribution throughout the entire capillary structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biosensor achieves simple manufacturing, rapid sample introduction, and minimizes the impact of capillary wall friction, enhancing the efficiency of the sample introduction process.
Implementation Method 1
a capillary structure is typically used to introduce a biomaterial such as a sample into a measuring region of the biosensor
Data Source
AI summary
The present invention relates to an apparatus for measuring biomaterial and a method for manufacturing thereof. The apparatus of the present invention comprises: a first substrate having a recess in one side thereof; a second substrate having a plurality of reaction electrodes where a biochemical reaction of a biomaterial occurs, and a plurality of delivery electrodes delivering signals from the reaction to a detector; and reaction reagents located in the recess causing the reaction with the biomaterial. The second substrate is attached to the first substrate such that a portion of the recess forms a sample-inlet, the recess cooperates with at least one edge of the second substrate to form at least one vent slit, and the reaction electrodes are directed toward the recess. Such apparatus of the present invention enables air in the capillary to be thoroughly and quickly discharged to the outside with biomaterial-introduction, thereby increasing the speed of the biomaterial-introduction.