Semiconductor Biosensor Cartridge With Dual-Loop Microfluidic Pumping
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Solution Overview
Problem
Existing electrical-based biomedical sensing devices are bulky and lack portability, making them unsuitable for convenient and high-quality diagnostics.
Innovation Solution
A portable semiconductor biosensor diagnostic system with a diagnostic cartridge that includes a biosensor chip for direct electrical signal conversion, utilizing a CMOS IC biosensor and a pumping mechanism to guide biomedical samples and buffer liquids to the biosensor chip.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If electrical-based biomedical sensing devices are used for high-quality diagnostics, then measurement precision is improved, but device complexity and size increase making them bulky and non-portable
Solution Approach 1:
The diagnostic system is divided into two separate components: a portable diagnostic cartridge for sample preparation and a separate reader device for signal detection. This segmentation allows the sensing functions to be distributed, making the cartridge small and portable while the reader handles the complex electrical measurements.
Solution Approach 2:
A fluid-guide body with integrated microchannels acts as an intermediary between the sample reservoir and the biosensor chip. This intermediary structure guides the biomedical sample through precise fluidic pathways to the sensing area, enabling portable operation while maintaining measurement precision through controlled sample delivery.
2Ease of operation
If a portable diagnostic device is created, then ease of operation is improved, but measurement precision may deteriorate due to sample handling challenges
Solution Approach 1:
The diagnostic cartridge incorporates a pumping mechanism that automatically draws the biomedical sample through the fluid-guide body and delivers it to the biosensor chip without manual intervention. This self-service approach maintains ease of portable operation while ensuring precise sample handling and positioning for accurate measurement.
Solution Approach 2:
Manual sample handling operations are replaced with an automated pumping mechanism integrated into the cartridge. This substitution maintains portability by eliminating the need for external mechanical handling equipment while improving measurement precision through consistent, controlled sample delivery to the sensor.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables high-quality, portable electrical-based diagnostics with precise signal conversion and amplification, suitable for low-dose sample detection, overcoming the limitations of bulky sensing devices.
Implementation Method 1
a pumping mechanism that the biomedical sample and the buffer liquid can be precisely guided to in contact with an electrical based biosensor chip
Implementation Method 2
biosensor chip for direct electrical signal conversion, utilizing a CMOS IC biosensor
Data Source
AI summary
A semiconductor biosensor diagnostic system is provided. The semiconductor biosensor diagnostic system includes a diagnostic cartridge and a cartridge diagnostic base. The diagnostic cartridge includes a biosensor device and a fluid-guide body over the biosensor device. The fluid-guide body includes a first pumping opening, a second pumping opening, a buffer reservoir, a sample reservoir, and a plurality of channels configured to provide a first loop including the first pumping opening and the buffer reservoir, and a second loop including the second pumping opening and the sample reservoir. The first loop and the second loop sharing a common channel passing through the biosensor device. The cartridge diagnostic base includes a plurality of micro pumps coupled to the first pumping opening and the second pumping opening, and a sensing structure configured to receive a sensing information from the biosensor device.