Biosensor Cartridge Plasma Separation and Metering
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Solution Overview
Problem
Conventional biosensor technologies require complex manual processes for detecting biological materials, which are time-consuming and prone to experimental errors, necessitating the development of automated systems for efficient and accurate analysis.
Innovation Solution
A biosensor cartridge utilizing microfluidic control technology that automates the reagent preprocessing and reaction process, incorporating a plasma separator, plasma metering chamber, mixer, and biosensor, along with additional components like fluidic valves and air-bubble removers, to facilitate automated blood-based biosensing, reducing manual intervention and improving detection accuracy and efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If manual processes are used for biosensor-based analysis, then flexibility and adaptability are maintained, but the process is time-consuming and prone to experimental errors
Solution Approach 1:
The system is divided into distinct functional modules including plasma separator, metering chamber, mixer, and biosensor chamber, each performing a specific function. This segmentation enables automated sequential processing while maintaining process reliability and reducing manual intervention time.
Solution Approach 2:
The cartridge is designed to automatically perform all processing steps from plasma separation to detection without external manual operation. The system self-regulates fluid flow, mixing, and detection processes, eliminating human error and reducing analysis time while maintaining high reliability.
2Measurement precision
If complex manual processing steps are performed, then comprehensive analysis is achieved, but the process becomes time-consuming and error-prone
Solution Approach 1:
Multiple processing functions (separation, metering, mixing, detection) are merged into a single integrated cartridge system. This consolidation maintains comprehensive analysis capability while simplifying operation and reducing the complexity of manual multi-step processing.
Solution Approach 2:
The cartridge is designed as a universal platform that can perform various biosensor-based analyses through automated processing. The multi-functional design enables precise detection across different applications without requiring complex manual procedures for each specific analysis.
3Productivity
If automated microfluidic control is implemented, then analysis efficiency is improved, but device complexity increases
Solution Approach 1:
The system uses pneumatic pressure control to automate fluid flow through the microfluidic channels. Pressure differential drives plasma separation, metering, and transport through the cartridge, enabling automated high-efficiency processing through a relatively simple pressure control mechanism rather than complex mechanical or electronic systems.
Solution Approach 2:
A porous membrane is used for plasma separation, utilizing the natural filtration properties of porous materials to separate plasma from blood components. This passive separation mechanism improves analysis efficiency while avoiding the need for complex active separation devices.
4Reliability
If multiple processing chambers are integrated, then comprehensive biosensing is achieved, but manufacturing complexity increases
Solution Approach 1:
The cartridge employs a nested structure where smaller functional chambers (separation chamber, metering chamber, mixing chamber) are arranged sequentially within the overall cartridge housing. This nested arrangement enables comprehensive multi-step processing while facilitating modular manufacturing and assembly, improving ease of production without compromising detection reliability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biosensor cartridge enables rapid, accurate, and cost-effective detection of biological materials by automating the entire process from reagent preprocessing to final detection, minimizing experimental errors and enhancing the efficiency of biosensing processes.
Implementation Method 1
The plasma separation filter may be connected to a lower end of the blood injector, and may block corpuscles in the blood and only pass the plasma
Implementation Method 2
The pressurizing channel may be connected to an upper end of the blood injector, and may apply air pressure to the blood in the blood injector
Implementation Method 3
A fluid path is defined by the contacting plasma guiding plate having the fine structure and plasma separation filter, so that a capillary action is generated in the fluid path
Implementation Method 4
The air-bubble remover may be between the mixer and the biosensor, and may remove air bubbles from the mixed solution before the mixed solution is injected into the biosensor
Data Source
AI summary
A biosensor cartridge includes a plasma separator, a plasma metering chamber, a mixer, and a biosensor.