Biosensor Co-Polymer Membrane for Interferent Exclusion
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Solution Overview
Problem
Existing biosensing systems face challenges in effectively excluding interfering species from analyte media due to the inefficiency of their interface membranes, which can allow similar-sized interfering substances to pass through, leading to inaccurate measurements.
Innovation Solution
A biosensing system comprising a substrate with a working electrode, a detection layer including metallic nanoparticles and a peptide probe, a biocompatible membrane made of triblock polymers, and a blank electrode, along with a DC power supply and AC impedance measuring unit, which uses a specific algorithm to determine analyte concentration by measuring direct currents and AC impedances.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a conventional interface membrane is used to allow analyte diffusion, then analyte detection is enabled, but interfering species of similar size can pass through causing measurement inaccuracy
Solution Approach 1:
The patent changes the physical-chemical parameters of the membrane by incorporating triblock copolymers with specific hydrophilic and hydrophobic segments. This creates a membrane with tuned pore size distribution and surface properties that selectively permits analyte diffusion while blocking interfering species based on their size and chemical characteristics, thereby improving measurement precision without sacrificing analyte detection capability
Solution Approach 2:
The patent employs a composite membrane structure combining triblock copolymer materials with distinct functional segments. The hydrophilic segments facilitate analyte transport while the hydrophobic segments create steric and chemical barriers to interfering species. This composite approach enables simultaneous achievement of high analyte permeability and interferent exclusion, resolving the contradiction between measurement accuracy and interferent blocking
2Measurement precision
If the biocompatible membrane is made more selective to exclude interferents, then measurement accuracy improves, but membrane complexity increases
Solution Approach 1:
Rather than creating complex multi-layer structures, the patent achieves high selectivity by carefully controlling the parameters of a single triblock copolymer system. By adjusting the molecular weight, composition ratio, and architecture of the hydrophilic and hydrophobic segments, the membrane's selective properties are tuned to provide excellent interferent exclusion with relatively simple single-layer construction, thus improving precision without proportionally increasing complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enhances the exclusion of interfering signals, providing more accurate and reliable analyte concentration measurements by effectively filtering out unwanted species and improving the stability and linearity of current output in response to analyte concentrations.
Implementation Method 1
The purpose of this interface membrane is to allow the diffusion of analytes into the detection layer while excluding potential interfering species
Implementation Method 2
B is a hydrophobic hard segment
Implementation Method 3
the detection layer comprises a metallic nanoparticle, polydopamine, and a peptide probe
Implementation Method 4
Electrochemical biosensors that employ biological recognition systems and electrochemical transudation
Data Source
AI summary
A biosensing system having biosensors coated with co-polymers and their uses thereof includes a substrate, a working electrode on top of the substrate, a detection layer on top of the working electrode, a biocompatible membrane on top of the detection layer, a blank electrode, wherein the blank electrode is substantially same as the working electrode and covered directly by the biocompatible membrane, a reference electrode, and a counter electrode; a DC power supply; a current measuring unit; an AC impedance measuring unit; a circuit switch; a control unit; and a data processing unit, wherein the peptide probe includes an enzyme, an antibody, or a polymer comprising a peptide, wherein the peptide probe includes an oxidoreductase, wherein the peptide probe includes glucose oxidase, glucose dehydrogenase, or horseradish peroxidase, wherein the metallic nanoparticle is a platinum nanoparticle, a gold nanoparticle, or an iridium nanoparticle.