Semiconductor Biosensor with Conducting Wires for Precision Detection
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Solution Overview
Problem
Conventional semiconductor biosensors are large and expensive, limiting their use to only large hospitals, and require extended inspection periods, making them costly and inconvenient for small-scale medical facilities, while also struggling to achieve precise detection of chemical substances.
Innovation Solution
A semiconductor biosensor with a central reaction unit comprising multiple semiconductor conducting wires, non-volatile memory type transistors, sense-amplifiers, and a bit line controller, embedded in a semiconductor chip, which allows for precise and compact detection by distinguishing signal changes from individual conducting wires and reducing noise through data-thinning and threshold voltage tuning.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional semiconductor biosensors are used, then detection precision can be achieved, but the device size becomes large and cost increases
Solution Approach 1:
The invention divides the detection system into multiple independent conducting wires (e.g., 3 wires) that can be integrated on a single chip. Each wire provides independent detection capability, allowing the system to achieve high precision through multiple measurements while maintaining a compact form factor that can be housed in small medical facilities.
2Measurement precision
If conventional semiconductor biosensors are used, then detection precision can be achieved, but inspection time increases to several days
Solution Approach 1:
The invention implements continuous monitoring capability through multiple conducting wires that can simultaneously detect target substances. The system continuously measures electrical characteristics and compares them against reference values, enabling real-time detection rather than batch processing, thereby reducing inspection time from several days to much shorter durations.
3Measurement precision
If multiple conducting wires are used to improve detection precision, then signal accuracy increases, but noise from wire errors increases
Solution Approach 1:
The invention implements a feedback mechanism where the controller continuously monitors the electrical characteristics of each conducting wire and compares them against pre-stored reference values. When a wire error is detected (such as anomalous resistance or snapped wires), the system identifies and excludes the faulty wire's data from the final measurement, thereby maintaining high signal accuracy while filtering out noise from defective wires.
Solution Approach 2:
The invention changes the parameter being monitored by measuring multiple different electrical characteristics (such as resistance, capacitance, or other electrical properties) across the conducting wires. By varying the measurement parameters and comparing results against reference values, the system can distinguish between genuine target substance signals and noise from wire errors, thereby improving signal-to-noise ratio.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration enables a highly precise and compact biosensor that significantly reduces the limit of detection, enhancing performance and reducing medical costs by enabling early disease detection and minimizing inspection time.
Implementation Method 1
non-volatile memory type transistor connected to said another end of each conducting wire
Implementation Method 2
a plurality of sense-amplifiers respectively connected to the non-volatile memory type transistors
Data Source
AI summary
A semiconductor biosensor and a control method thereof are disclosed for enhancing performance of semiconductor biosensor and the reducing price of medical healthcare chip. An embodiment of the semiconductor biosensor includes a central reaction unit (200). The central reaction unit (200) comprises a plurality of semiconductor conducting wires (6); a common source (2), wherein one end of each conducting wire (6) is connected to the common source (2); a plurality of non-volatile memory type transistors (31) respectively connected to another end of each conducting wire (6); a plurality of sense-amplifiers (9) respectively connected to the said non-volatile memory type transistors (31); a bit line controller (22) analyzing signals sensed by the said sense-amplifiers (9) and managing the operation of the said non-volatile memory type transistors (31); an oxide film (1) wrapping or covering the said conducting wires (6), and a plurality of receptors (8) fixed on a surface of the said oxide film (1).