Biosensor Measurement Accuracy via Detection Time Adjustment
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Solution Overview
Problem
Conventional biosensor measurement systems face inaccuracies due to temperature differences between the actual sample and the surrounding environment, especially when handled by users, leading to measurement errors in self-monitoring blood glucose systems, and existing solutions are either costly or have poor reproducibility.
Innovation Solution
A sample measurement device that measures the detection time of a biosensor from mounting to sample deposition and adjusts the measurement parameters, such as measurement time or applied voltage, to minimize the impact of temperature variations, using a controller and time measurement component to ensure accurate readings.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If temperature correction is performed using environment temperature, then measurement accuracy is improved, but measurement error due to sample temperature difference remains
Solution Approach 1:
The patent replaces the mechanical/physical temperature measurement approach with a chemical substitution method. By using a reference sample with known analyte concentration and performing parallel measurements, the system substitutes direct temperature sensing with a comparative chemical analysis approach that inherently compensates for temperature effects without requiring temperature sensors or correction algorithms.
Solution Approach 2:
The patent introduces a reference sample as an intermediary element. This reference sample acts as a mediator that experiences the same temperature conditions as the actual sample, allowing the system to indirectly measure and compensate for temperature effects through comparative analysis rather than directly measuring temperature.
2Measurement precision
If additional temperature sensors are added to measure sample temperature, then measurement accuracy is improved, but device complexity and cost increase
Solution Approach 1:
The patent eliminates the need for temperature sensors by substituting the physical measurement approach with a chemical comparative method. The measurement system uses only the existing biosensor and measurement device, replacing complex temperature sensing and correction infrastructure with a simple reference sample measurement approach.
Solution Approach 2:
The patent creates a copy of the measurement process using a reference sample. By performing an identical measurement procedure on a reference sample with known concentration, the system obtains a reference signal that captures all environmental and temperature effects, which is then used to correct the actual sample measurement without requiring additional sensors.
3Productivity
If measurement is performed quickly with short detection time, then productivity is improved, but measurement accuracy deteriorates due to temperature variations
Solution Approach 1:
The patent performs a preliminary measurement on a reference sample before measuring the actual sample. This preliminary action establishes a baseline that accounts for temperature and environmental conditions, allowing rapid subsequent measurements to be corrected using this pre-obtained reference data, thus maintaining both speed and accuracy.
Solution Approach 2:
The patent implements a feedback mechanism where the reference sample measurement result is used to correct the actual sample measurement. The reference measurement provides feedback about environmental conditions, which is then applied to adjust and improve the accuracy of the productivity-critical actual measurements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach reduces measurement errors and provides highly accurate results with minimal deviation from true values, even with short detection times, without the need for additional temperature sensors, thus improving the reliability and cost-effectiveness of biosensor measurements.
Implementation Method 1
a reagent layer 35, and an insulated substrate 36... The reagent layer 35 supports a reagent that undergoes an enzyme reaction with a specific component in a liquid sample
Implementation Method 2
when blood is deposited in the sample supply port 34a of the biosensor 30, the blood seeps along the sample supply path 34 by capillary action
Data Source
AI summary
A sample measurement device (110), in which a biosensor (30) having an electrode is mounted, voltage is applied to the electrode, and the concentration of a specific component in a sample deposited on the biosensor (30) is measured, comprises a voltage source (19) configured to apply voltage to the electrode, a time measurement component (22), and a controller (18) configured to control the voltage to be applied and measure the concentration of the specific component. The time measurement component (22) measures a detection time, which is the length of time between the mounting of the biosensor (30) and the deposition of a sample on the biosensor (30). The controller (18) changes a set value for measuring the concentration of a specific component according to the detection time. Consequently, measurement accuracy can be improved regardless of the temperature of the biosensor (30).