Biosensor Electrode System for Hct-Corrected Blood Component Measurement
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Solution Overview
Problem
Conventional methods for measuring blood component amounts, such as glucose levels, are affected by hematocrit (Hct) values, leading to inaccuracies in correction and measurement reliability.
Innovation Solution
A biosensor system with multiple electrode systems and a reagent portion configuration that allows for simultaneous voltage application to reduce Hct's impact, enabling the calculation of a true blood component amount by detecting and correcting for Hct effects through specific current values.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional single electrode system is used, then device complexity is low, but measurement precision is reduced due to Hct effects
Solution Approach 1:
The sensor is divided into multiple electrode systems (first electrode system with first working electrode and first counter electrode, second electrode system with second working electrode and second counter electrode). Each electrode system independently measures current values that are subsequently processed to eliminate Hct effects, thereby improving measurement precision without requiring a single complex electrode configuration.
Solution Approach 2:
The patent uses current values detected from multiple electrode systems as intermediary measurements. By detecting a first current value from the first electrode system and a second current value from the second electrode system, and using these as intermediaries to calculate the blood component amount while correcting for Hct effects, the system achieves higher precision measurement.
2Reliability
If Hct correction is applied using conventional methods, then measurement accuracy is improved, but reliability is reduced due to insufficient correction
Solution Approach 1:
The system implements feedback by using the second current value detected from the second electrode system to correct the first current value from the first electrode system. This feedback mechanism allows the system to account for Hct effects and improve both the accuracy of Hct measurement and the reliability of the final blood component amount measurement.
Solution Approach 2:
The patent employs a composite measurement approach by combining measurements from multiple electrode systems with different configurations. The first electrode system and second electrode system use different reagent portions and detection methods, and their combined results provide a more reliable and accurate measurement that compensates for the limitations of individual systems.
3Measurement precision
If multiple electrode systems with reagent portions are used, then Hct effects are reduced, but device complexity increases
Solution Approach 1:
Different reagent portions are applied to different electrode systems according to their specific functions. The first reagent portion is applied to the first working electrode for primary detection, while the second reagent portion is applied to the second working electrode for Hct-related measurements. This local differentiation of reagent quality enables precise measurement while managing complexity through functional specialization.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method improves the accuracy of blood component measurements by minimizing the Hct's influence, resulting in more reliable and precise calculations of blood component amounts.
Implementation Method 1
An oxidation-reduction reaction occurs between components of the blood and the oxidoreductase, so that a current flows via the mediator
Implementation Method 2
The blood is sucked into the flow path of the sensor by capillary action
Data Source
AI summary
Provided is a method for measuring a blood component amount that can sufficiently and properly correct the blood component amount by measuring an Hct value with high accuracy and high reliability, and a sensor and a measuring device that are used in the method.A method for measuring a blood component amount uses a biosensor to calculate a blood component amount in blood. The biosensor includes the following: a first electrode system having a first working electrode and a first counter electrode; a second electrode system having a second working electrode and a second counter electrode; and a reagent portion arranged in a form that covers at least a part of the first electrode system, but does not cover the second working electrode. The method includes the following: a first step of detecting a first current value that flows through the first electrode system and calculating an apparent blood component amount in the blood based on the first current value, during a period in which a first voltage is applied to the first electrode system and a second voltage is applied to the second electrode system while the first voltage is being applied; followed by a second step of stopping the application of the first voltage to the first electrode system, applying a third voltage to the second electrode system, and detecting a second current value; and a step of calculating a true blood component amount using the apparent blood component amount and the second current value.