Electrochemical Biosensor Electrode Segmentation for Timing Precision
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Solution Overview
Problem
Conventional electrochemical biosensors face challenges in accurately measuring bio samples due to double layer capacitance distortion and variability in sample insertion timing and velocity, which affects measurement accuracy and reproducibility.
Innovation Solution
The electrochemical biosensor structure features a working electrode and reference electrode with projections and recesses alternately arranged, along with separate sample recognition electrodes, allowing independent sample recognition signals to determine sample arrival and velocity, minimizing double layer capacitance effects and enabling precise measurement timing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a sample detection signal is applied to a working electrode and a reference electrode to detect the sample insert timing, then the sample insert timing can be detected, but the detection signal forms an electric double layer on the electrode surface causing distortion of the measurement signal
Solution Approach 1:
The patent divides the electrode system into separate functional groups: sample recognition electrodes (first and second) for detecting sample insertion timing, and sample measurement electrodes (working and reference) for actual measurement. This segmentation allows the detection function to be separated from the measurement function, preventing the detection signal from causing double layer capacitance distortion on the measurement electrodes while maintaining accurate timing detection capability.
2Measurement precision
If the measurement begins after an elapse of predetermined time calculated from sample insert timing, then the sample accumulation can be completed, but the sample viscosity affects the accumulating velocity causing inaccuracy in measurement timing
Solution Approach 1:
The patent employs a feedback mechanism where the first sample recognition electrode detects sample insertion and triggers timing control, and the second sample recognition electrode detects sample arrival at the measurement area. This feedback loop allows the system to dynamically adjust the measurement timing based on actual sample accumulation status rather than relying on predetermined fixed time delays, thereby compensating for variations in sample viscosity and accumulation velocity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration reduces signal distortion, allows for accurate and rapid sample measurement, and improves reproducibility by controlling sample insertion timing and velocity, regardless of sample viscosity.
Implementation Method 1
The biosensor is composed of an identification part for identifying an analyte target, and a conversion part that is in charge of conversion to electrical signals. Biomaterials are used as the identification part of the biosensor. The biomaterial recognizes an analyte target to cause a chemical or physical change, and the conversion part converts the chemical or physical change to electrical signals.
Implementation Method 2
the measurement method using the conventional strip type biosensor involves inserting a sample into a sample insertion path by way of capillary action, which is stronger than terrestrial gravity
Data Source
AI summary
The present invention provides there is provided an electrochemical biosensor electrode structure that includes: a working electrode and a reference electrode used as electrodes for sample measurement being arranged separately from each other in lengthwise direction of a sample insertion path, the working electrode and the reference electrode each having at least one projection and at least one recess alternately arranged on a portion thereof corresponding to the sample insertion path, the projection of the working electrode being correspondingly adjacent to the recess of the reference electrode, the recess of the working electrode being correspondingly adjacent to the projection of the reference electrode; and at least two sample recognition electrodes used as electrodes for sample recognition being separated from each other and arranged adjacent and parallel to the working electrode and the reference electrode. The present invention minimizes the effect of the double layer capacitance and independently applies the sample recognition signal to accurately detect the sample insert time and velocity.