Biosensor Electrode Timing for Accurate Blood Target Measurement
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Solution Overview
Problem
Existing biosensors face challenges in accurately measuring blood targets when additional spot-applications occur, leading to incorrect readings due to variations in reagent availability and reaction rates.
Innovation Solution
A measurement method using upstream and downstream electrode pairs with time difference measurements to correct for additional spot-applications, involving first and second detection steps, time measurement, and parameter correction based on time differences.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If additional spot-application of blood is performed on the biosensor, then more blood sample can be supplied, but measurement accuracy deteriorates due to reagent depletion and reaction rate variations
Solution Approach 1:
The patent applies preliminary action by detecting the arrival of blood at the upstream electrode pair before the actual measurement begins. This allows the system to prepare for potential additional spot-applications by establishing a time reference point, enabling subsequent correction of measurement values based on the time difference between blood arrivals.
Solution Approach 2:
The patent implements feedback by using the downstream electrode pair to detect blood arrival and calculate the time difference from the upstream detection. This time difference information is fed back to correct the measurement value, compensating for the effects of additional spot-applications on reagent availability and reaction rates.
2Device complexity
If traditional single electrode pair detection is used, then device complexity is reduced, but inability to detect additional spot-applications causes measurement errors
Solution Approach 1:
The patent applies segmentation by dividing the detection function into two separate electrode pairs positioned at different locations along the blood flow path. The upstream electrode pair detects initial blood arrival, while the downstream electrode pair detects subsequent arrival, allowing the system to identify additional spot-applications and correct measurements accordingly.
Solution Approach 2:
The patent uses the time difference measurement as an intermediary parameter to bridge the detection of blood arrival and the correction of measurement values. This intermediary approach allows the system to translate temporal information from dual electrode detection into quantitative correction factors for accurate target measurement.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Ensures accurate measurement of blood targets by accounting for additional spot-applications, enhancing reaction rates and reagent availability, thereby improving measurement precision.
Implementation Method 1
a flow path for guiding a spot-applied liquid specimen to a measurement electrode by capillary action
Data Source
AI summary
Using a biosensor including a flow path into which blood containing a target is introduced, an upstream electrode pair disposed in the flow path and having a reagent reacting with the target disposed on either of the electrodes, and a downstream electrode pair disposed at a downstream side of the flow path; the method includes a first detection step of detecting a first introduction of blood as far as the upstream electrode pair; a second detection step of detecting a second introduction of blood as far as the downstream electrode pair; a time measurement step of measuring a time difference from the first introduction to the second introduction; and a measurement step of acquiring the value related to the target based on the time difference by using any two electrodes among the upstream and downstream electrode pair after the second introduction is detected.