Bio Sensor Electrode Array Voltage Alternation
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Solution Overview
Problem
Electrochemical bio sensors face challenges in ensuring reproducibility during continuous measurements due to interference from substances in biological fluids adhering to the electrode, which existing protective layers cannot effectively prevent, especially for smaller interfering substances.
Innovation Solution
A bio sensor system that includes an electrode array with an enzyme electrode, a power driver, and a processor that alternately applies negative and positive voltages, followed by a measurement voltage after a preset time, to restore the enzyme electrode to its initial state and prevent interference, enhancing reproducibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If an electrode protective layer with micro pores is used to prevent interfering substances from adhering to the electrode, then the electrode is protected from larger interfering substances, but smaller interfering substances can still penetrate through the micro pores and cause measurement interference
Solution Approach 1:
The patent changes the electrical parameter (voltage) applied to the electrode over time. By alternately applying positive and negative voltages before measurement, the system dynamically adjusts the electrode's electrical state to prevent adsorption of interfering substances of various sizes, thereby maintaining measurement precision without compromising protective function
Solution Approach 2:
The patent applies preliminary voltage treatment (alternating positive and negative voltage) to the electrode before performing the actual measurement. This preliminary action cleans or conditionsthe electrode surface in advance, preventing interfering substances from adhering during the measurement process, thus ensuring accurate measurements
2Productivity
If continuous measurement is performed using an electrochemical bio sensor, then monitoring capability is improved, but reproducibility deteriorates due to accumulation of interfering substances on the electrode
Solution Approach 1:
The patent implements periodic voltage reversal during continuous measurement operations. By regularly alternating between positive and negative voltage states, the system periodically refreshes the electrode surface condition, preventing cumulative adsorption of interfering substances and maintaining consistent measurement reproducibility throughout continuous operation
Solution Approach 2:
The system performs self-maintenance of the electrode through automatic voltage alternation. The bio sensor autonomously applies positive and negative voltage sequences to clean or recondition the electrode surface during continuous use, eliminating the need for external manual cleaning while maintaining measurement reliability
3Reliability
If voltage is applied to restore the enzyme electrode to its initial state, then measurement reproducibility is improved, but additional time is required for voltage application and stabilization
Solution Approach 1:
The patent integrates the voltage restoration process into the continuous measurement workflow without creating idle time. The alternating voltage application and measurement process is designed to flow continuously, where the voltage alternation serves both as a cleaning mechanism and as part of the measurement sequence, eliminating separate stabilization periods
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly improves the reproducibility and accuracy of continuous measurements by effectively removing interfering substances and maintaining the enzyme's oxidation state, as demonstrated by enhanced linearity and accuracy in glucose concentration measurements.
Implementation Method 1
An electrochemical bio sensor is a device for measuring the amount of a measurement target material via a method of detecting an electrochemical through an enzyme reaction with the measurement target material using an enzyme electrode formed by fixing an enzyme to an electrode
Implementation Method 2
The enzyme electrode may include an enzyme for oxidizing glucose
Implementation Method 3
An operation principle of a bio sensor for measuring one or more analytes in biological fluids is mainly based on an electrochemical method
Data Source
AI summary
A bio sensor a method of sensing for the bio sensor are provided. The bio sensor includes an electrode array. The electrode array includes an enzyme electrode for measuring a target material, a power driver for providing a voltage to the electrode array, and a processor for controlling the power driver to alternately provide a negative voltage and a positive voltage to the electrode array, and for controlling the power driver to provide a measurement voltage for measuring the target material to the electrode array after the alternating voltage is provided.