Biosensor Error Compensation via Pseudo-Reference and Anchor Parameters
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Solution Overview
Problem
Biosensor systems face challenges in accurately determining analyte concentrations due to system and output signal errors, which affect measurement performance and require improved methods for error compensation.
Innovation Solution
The method involves generating output signals from a sample, determining pseudo-reference concentration values, and using anchor parameters to compensate for system errors, incorporating these into a compensation relationship to calculate final analyte concentrations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional measurement methods are used to determine analyte concentration, then the measurement process is simple, but system errors and output signal errors reduce measurement accuracy and precision
Solution Approach 1:
The patent introduces pseudo-reference concentration values and anchor parameters as intermediary elements that mediate between the raw output signals and the final analyte concentration determination. These intermediaries enable the system to account for both system errors and output signal errors without requiring direct measurement of the errors themselves, thus improving measurement accuracy while maintaining manageable system complexity
Solution Approach 2:
The patent transforms the error compensation approach by changing from direct error measurement to using derived parameters (pseudo-reference concentration values and anchor parameters). This parameter transformation allows the system to compensate for errors through mathematical relationships rather than direct physical measurements, resolving the contradiction between accuracy improvement and system complexity
2Reliability
If system error compensation is implemented, then measurement accuracy improves, but the complexity of the measurement system increases
Solution Approach 1:
The system performs self-diagnosis and self-correction by using its own output signals to generate pseudo-reference concentration values and anchor parameters. The measurement system automatically identifies and compensates for its own errors without requiring external calibration or additional reference measurements, thereby improving reliability while avoiding the complexity of external compensation systems
Solution Approach 2:
The patent implements a feedback mechanism where the measured output signals are fed back through the pseudo-reference concentration and anchor parameter calculations to adjust and compensate for system errors. This closed-loop feedback approach continuously improves measurement reliability by using the system's own operational data to correct its performance
Data Source
AI summary
During analyte analysis, errors may be introduced into an analysis by both the biosensor system used to perform the analysis and by errors in the output signal measured by the measurement device of the biosensor. For a reference sample, system error may be determined through the determination of relative error. However, during an analysis of a test sample with the measurement device of the biosensor system, true relative error cannot be known. A pseudo-reference concentration determined during the analysis may be used as a substitute for true relative error. The present invention introduces the determination of a pseudo-reference concentration determined during the analysis as a substitute for the true relative error and uses an anchor parameter to compensate for the system error in the analysis-determined pseudo-reference concentration.