Biosensor Flow Stop Area for Sample Timing Control
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Solution Overview
Problem
Conventional biosensors face challenges in measuring biochemical markers like 1,5-anhydroglucitol due to the immediate arrival of samples at the electrode, making it difficult to perform pre-treatment reactions required for accurate detection.
Innovation Solution
A biosensor design featuring a sample flow channel with a hydrophilic section and a flow stop area, allowing controlled sample timing at the electrode system, and incorporating a sample retaining area for stable sample holding and pre-treatment reagent placement for interfering substance removal.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If the sample is supplied immediately to the electrode system, then the measurement speed is improved, but the ability to perform pre-treatment reactions is worsened
Solution Approach 1:
The patent introduces a flow stop area that temporarily halts the sample flow before the sample reaches the electrode system. This allows pre-treatment reactions to occur in advance (removing interfering substances like glucose) while maintaining overall measurement efficiency. The sample is stopped only when needed, performing preliminary actions without significantly delaying the overall process.
2Measurement precision
If a flow stop area is introduced to control sample timing, then the measurement accuracy is improved, but the device complexity is worsened
Solution Approach 1:
The patent applies local quality by creating a specific zone (flow stop area) with distinct properties within the sample flow channel. This localized modification allows the sample to be stopped only in a specific region, enabling pre-treatment reactions without requiring complex system-wide modifications. The hydrophobic coating or structural feature is applied locally rather than throughout the entire device.
3Measurement precision
If the sample is retained for pre-treatment reactions, then the measurement accuracy is improved, but the measurement time is worsened
Solution Approach 1:
The patent employs dynamics by making the sample flow controllable - the sample flow rate and timing are dynamically adjusted to allow retention in the flow stop area only when pre-treatment is needed. The system transitions between different flow states (flowing vs. stopped) based on the measurement requirements, optimizing both accuracy and time efficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise control of sample timing at the electrode system, facilitating accurate measurements even for markers requiring pre-treatment, thereby improving measurement efficiency and accuracy.
Implementation Method 1
a hydrophilic section provided on at least a part of the internal surface of the sample flow channel and extending from a first end near the electrode system to a second end on the opposite side
Implementation Method 2
a flow stop area provided on a section adjacent to the second end on the first member or on the internal surface of the sample flow channel to temporarily stop the flow of the sample into the electrode system
Data Source
AI summary
A biosensor for electrochemically measuring a sample may include a first member made of an insulating material, an electrode system including a working electrode and a counter electrode formed on the first member, a second member fixed over the first member, a sample flow channel provided between the first member and the second member, a hydrophilic section provided on at least a part of the internal surface of the sample flow channel and extending from a first end near the electrode system to a second end on the opposite side, and a flow stop area provided on a section adjacent to the second end on the first member or on the internal surface of the sample flow channel.