Biosensor Hematocrit Electrode Coating for Glucose Measurement
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing biosensors for blood glucose monitoring face challenges due to the influence of hematocrit values, leading to inaccurate glucose level measurements, as they either increase power consumption or require complex sensor structures with unstable separation membranes.
Innovation Solution
A biosensor system with a hematocrit electrode coated with a water-soluble electrically conductive polymer, such as polyaniline, is used to measure hematocrit values and correct glucose concentration measurements by applying specific voltages to the working and hematocrit electrodes, allowing for accurate glucose level determination.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If alternating voltage is applied to measure hematocrit value, then hematocrit measurement is enabled, but power consumption increases and measurement accuracy decreases due to noise
Solution Approach 1:
The patent changes the voltage parameter from alternating voltage to constant voltage (0-400 mV range) for hematocrit measurement. This parameter change eliminates the need for complex alternating voltage generation while enabling accurate hematocrit measurement through constant voltage application to the hematocrit electrode, thereby reducing power consumption and simplifying the measurement system.
2Measurement precision
If separation membrane is used to separate blood plasma from whole blood, then glucose measurement accuracy is improved, but device complexity increases and separation stability decreases
Solution Approach 1:
The patent extracts the hematocrit measurement function from the glucose measurement system by adding a separate hematocrit electrode. This allows independent measurement of hematocrit value, which is then used to correct glucose measurements mathematically, eliminating the need for physical separation membranes and their associated complexity and stability issues.
Solution Approach 2:
The patent introduces hematocrit value as an intermediary parameter that mediates between whole blood glucose measurement and plasma glucose concentration. By measuring hematocrit separately and using it as a correction factor in calculations, the system achieves accurate glucose measurement without requiring physical separation of plasma from whole blood.
3Measurement precision
If separation membrane is used to prevent hematocrit influence, then glucose measurement accuracy is improved, but separation ability becomes unstable due to sample viscosity
Solution Approach 1:
The patent implements a feedback mechanism where hematocrit value is measured and then used to correct the glucose measurement result. The system continuously monitors hematocrit and adjusts the glucose calculation accordingly, providing a reliable correction that compensates for hematocrit influence without requiring unstable separation membranes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables easy and accurate measurement of hematocrit values and glucose concentrations, reducing measurement noise and power consumption while simplifying the sensor structure, thereby improving the accuracy and efficiency of glucose monitoring.
Implementation Method 1
measuring the value of a second current which flows when a voltage of 100 to 300 mV is applied to the hematocrit electrode
Implementation Method 2
measuring the value of a first current which flows when a voltage of 0 to 400 mV is applied to the working electrode
Data Source
AI summary
Provided is a method for measuring the concentration of a substance in a blood sample, the method comprising the steps of: supplying the blood sample to a biosensor comprising a hematocrit electrode for measuring a hematocrit value on the surface of which electrode an electrically conductive polymer is coated by physical adsorption in the absence of a crosslinking agent; and calculating the concentration of the substance from the measured value of a first current resulting from application of a first voltage; and correcting the concentration of the substance with the value of a second current resulting from application of a second voltage or the hematocrit value calculated from the value of the second current.