Biosensor Capillary Hematocrit Measurement via Multi-Electrode Segmentation
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Solution Overview
Problem
Conventional biosensors face challenges in accurately measuring blood components due to uneven distribution of blood in capillaries, which affects the measurement of hematocrit and subsequent correction of blood component levels.
Innovation Solution
The implementation of multiple electrode systems within the biosensor, allowing for hematocrit measurement at various positions, enabling more accurate blood component analysis by applying specific voltages to each system and using the resulting current values to calculate the blood component levels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a single electrode system is used for hematocrit measurement, then the device complexity is low, but the measurement precision deteriorates due to uneven blood distribution in the capillary
Solution Approach 1:
The single electrode system is divided into multiple electrode systems (first, second, third electrode systems) positioned at different locations within the capillary. Each electrode system independently measures hematocrit at its specific position, allowing the system to capture the variability of blood distribution throughout the capillary rather than relying on a single measurement point.
Solution Approach 2:
Different electrode systems are placed at different positions within the capillary to measure local hematocrit values. The first electrode system measures at one location, the second at another, and the third at a third location, recognizing that blood distribution is not uniform throughout the capillary volume.
2Measurement precision
If multiple electrode systems are implemented to measure hematocrit at different positions, then the measurement precision improves, but the device complexity increases
Solution Approach 1:
The multiple electrode systems serve dual functions: they measure hematocrit at different positions within the capillary and also provide data for calculating the average hematocrit value. This average value is then used to correct the blood component amount measurement, making the electrode systems multi-functional rather than requiring separate dedicated systems.
Solution Approach 2:
The hematocrit measurements from the multiple electrode systems are fed back into the calculation process to determine the average hematocrit value. This feedback mechanism allows the system to use the measured variability in hematocrit distribution to correct and improve the accuracy of the blood component amount measurement.
3Reliability
If hematocrit is measured at a single position, then the ease of operation is high, but the reliability of blood component correction deteriorates
Solution Approach 1:
The measurement process is segmented into multiple independent hematocrit measurements at different positions within the capillary. The first electrode system, second electrode system, and third electrode system each perform their measurement independently, and these segmented measurements are then combined to calculate the average hematocrit for correction purposes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method improves measurement accuracy even with uneven blood distribution, providing a more precise calculation of blood component amounts by considering the hematocrit values across different positions within the capillary.
Implementation Method 1
a first electrode system for measuring a first current value depending on a hematocrit level... applying a first voltage to the first electrode system and detecting a first current value
Implementation Method 2
The reagent layer 39 contains an oxidoreductase and a mediator... the component in the blood reacts with the oxidoreductase to cause an oxidation-reduction reaction, thereby causing a current to flow through the mediator
Implementation Method 3
The blood is drawn into the channel of the sensor by capillary action, introduced into the analysis portion through the channel
Data Source
Figure 1(a)~1(b)
Figure 2
Figure 3
AI summary
The present invention provides a method for accurately measuring a blood component despite uneven distribution of blood introduced into a capillary. The measurement method according to the present invention is characterized in that a plurality of electrode systems for measuring the hematocrit are provided in a capillary of a biosensor to measure the hematocrit at different positions in the capillary. By measuring the hematocrit at the plurality of positions in the capillary as described above, the hematocrit can be measured more accurately despite uneven distribution of blood introduced into the capillary.