Biosensor Integrated Drive Signal Lines Sealing
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Solution Overview
Problem
Current biosensors face challenges in accurately detecting biomolecule concentrations due to liquid volatilization and poor sealing when using external metal wires, leading to reduced accuracy and efficiency.
Innovation Solution
A biosensor design featuring a base substrate with detection units, a cover plate with recesses, and integrated drive signal lines, which forms a sealed detection cavity to reduce volatilization and enhance accuracy, utilizing a graphene layer and probe modification layers with antibody proteins for antigen detection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If external metal wires are used for electrical connection, then ease of manufacture is improved, but sealing performance deteriorates leading to liquid volatilization
Solution Approach 1:
The patent merges the electrical connection function and the sealing structure by integrating drive signal lines directly into the base substrate. This eliminates the need for separate external metal wires that compromised sealing, as the integrated lines are embedded within the substrate structure, allowing the cover plate to seal against the substrate surface without penetrating holes.
Solution Approach 2:
The patent replaces the mechanical wire insertion system with an integrated circuit board system. Instead of mechanically inserting metal wires through holes in the cover plate, the electrical connections are formed through printed circuit board traces or embedded conductors in the base substrate, eliminating the need for physical penetrations that would compromise the seal.
2Ease of operation
If holes are made in the cover plate for wire insertion, then ease of operation is improved, but measurement precision deteriorates due to liquid volatilization
Solution Approach 1:
The patent combines the electrical connection function with the base substrate structure itself. The drive signal lines are integrated into the substrate, eliminating the need for separate wire insertion operations through holes in the cover plate, thereby maintaining both ease of operation and detection accuracy.
Solution Approach 2:
The patent extracts the electrical connection function from the cover plate system and relocates it to the base substrate. By taking out the wire insertion requirement from the cover plate design, the system maintains operational simplicity while preserving the integrity of the liquid-containing chamber for accurate detection.
3Reliability
If integrated drive signal lines are used, then sealing performance is improved, but device complexity increases
Solution Approach 1:
The patent merges multiple functions into the base substrate: structural support, electrical connection pathways, and signal routing. By integrating drive signal lines directly into the substrate, the system achieves improved sealing without requiring additional separate components, as the substrate itself serves multiple purposes.
Solution Approach 2:
The base substrate is designed with multi-functionality, serving as both the structural foundation and the electrical connection medium. The integrated drive signal lines are embedded within the substrate structure, allowing the same component to provide both mechanical support and electrical pathways, thereby reducing overall device complexity despite the enhanced sealing requirement.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biosensor achieves improved sealing and accuracy in detecting biomolecule concentrations by eliminating the need for holes in the cover plate and integrating drive signal lines, reducing liquid volatilization and enhancing detection efficiency.
Implementation Method 1
the probe modification layer contains an antibody protein for reacting with a specific antigenic protein in a liquid under detection
Data Source
AI summary
Provided is a biosensor. The biosensor includes: a base substrate; a plurality of detection units disposed on a side of the base substrate, wherein each of the plurality of detection units includes a gate; a first drive signal line disposed on the side of the base substrate and electrically connected to the gate; and a cover plate fixedly connected to the side of the base substrate, wherein a plurality of recesses are defined in a side, proximal to the base substrate, of the cover plate.