Biosensor Imaging With Layered Filters for Real-Time Spectrum Shift
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Solution Overview
Problem
Existing biosensors face challenges in real-time detection of spectrum shifts due to high Q factor resonance, making it difficult to accurately measure surface characteristic changes when target biomolecules interact with receptors.
Innovation Solution
An imaging method using a photodiode array and filter array with single-layered and double-layered filters to simultaneously obtain multiple image signals, allowing for precise determination of spectrum shifts by comparing image intensities and employing equations to calculate signal values.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a high Q factor resonance is used in the biosensor, then the sensitivity of biomolecule detection is improved, but the real-time detection capability of spectrum shift deteriorates
Solution Approach 1:
The detection system is segmented into multiple independent detection channels, each equipped with specific filters (first filter, second filter, third filter) that operate at different wavelength ranges. This segmentation allows parallel measurement of spectrum shifts at multiple points simultaneously, enabling real-time detection while maintaining high sensitivity through the high Q factor resonance in each channel.
Solution Approach 2:
The system employs periodic scanning of the spectrum by modulating the light source wavelength and sequentially measuring intensity at different wavelength points. This periodic action allows the high Q factor resonance to be effectively utilized for sensitive detection while maintaining real-time capability through rapid sequential measurements that capture dynamic changes.
2Measurement precision
If multiple filters are used to detect spectrum shift, then the measurement precision is improved, but the device complexity increases
Solution Approach 1:
Multiple filters (first filter, second filter, third filter) are merged into a single integrated filter array structure that can be positioned close to the photodiode array. This merging reduces the overall system complexity by consolidating what would otherwise be separate filter assemblies, while still enabling multi-wavelength detection for accurate spectrum shift measurement.
Solution Approach 2:
The filter array is designed with universal applicability, where the same filter structure can detect spectrum shifts across different wavelength ranges by simply changing the filter configuration. This multi-functionality allows a single device design to handle various detection requirements without increasing fundamental structural complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enhances signal-noise ratio and enables real-time detection of spectrum shifts with improved accuracy, miniaturizing the biosensor and increasing flexibility in detection range.
Implementation Method 1
receiving a first light beam by a first photodiode and a second photodiode to simultaneously obtain a first image signal with a first image intensity from the first photodiode and a second image signal with a second image intensity from the second photodiode
Implementation Method 2
The first image signal corresponds to the first light beam filtered by a first filter, and the second image signal corresponds to the first light beam filtered by a first double-layered filter including a second filter overlapped on a third filter
Data Source
AI summary
This disclosure provides an imaging method for detecting spectrum shift and a biosensor for the imaging method. The imaging method includes receiving a first light beam by a photodiode array to simultaneously obtain a first image signal with a first image intensity corresponding to a first filter and a second image signal with a second image intensity corresponding to a double-layered filter including the first filter and a second filter; receiving a second light beam by the photodiode array to simultaneously obtain a third image signal with a third image intensity corresponding to the first filter and a fourth image signal with a fourth image intensity corresponding to the double-layered filter, and determining a spectrum shift from the first light beam to the second light beam by comparing the first and the second image intensity to the third and the fourth image intensity.