Biosensor Pixelated Filters Composite Structure
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Solution Overview
Problem
Existing biosensors face challenges with optical filters that are either non-angle-sensitive but prone to fluorescence and peeling issues, or angle-sensitive but difficult to pixelate, limiting their effectiveness in blocking excitation light and allowing emission light to enter sensing pixels.
Innovation Solution
A biosensor design incorporating a substrate with photodiodes, pixelated filters, an excitation light rejection layer, and an immobilization layer, where the pixelated filters are formed using techniques like sputtering and chemical vapor deposition to enhance adhesion and mechanical resistance, and the excitation light rejection layer prevents undesired fluorescence.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If an organic filter is used, then it is non-angle-sensitive and easy to pattern, but it generates strong fluorescence and has poor adhesion and chemical resistance
Solution Approach 1:
The patent combines organic color filters with inorganic dielectric interference filters in a composite structure. The organic filter provides ease of patterning and non-angle-sensitive properties, while the dielectric filter layer blocks fluorescence generation and provides chemical resistance. This composite approach resolves the contradiction by integrating the advantages of both material types.
2Object-generated harmful factors
If a dielectric interference filter is used, then it generates weak or no fluorescence and allows thickness adjustment, but it is angle-sensitive and difficult to pixelate
Solution Approach 1:
The patent divides the filter structure into pixelated regions where each pixel can have independently optimized dielectric interference filter characteristics. By segmenting the filter into discrete pixels with grid walls separating them, the system achieves both the fluorescence-blocking properties of dielectric filters and the pixelation capability needed for different passband and stopband configurations on neighboring pixels.
3Ease of manufacture
If an organic filter is used, then it is easy to pattern, but it has poor adhesion and chemical resistance leading to peeling issues
Solution Approach 1:
The patent creates a composite filter system where organic color filters are combined with inorganic dielectric layers and grid wall structures. The inorganic components provide superior adhesion and chemical resistance to prevent peeling, while the organic filter maintains ease of patterning. The grid walls further reinforce the structure and prevent delamination.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides stronger adhesion and chemical or mechanical resistance to pixelated filters, preventing peeling issues and effectively blocking excitation light, while allowing emission light to enter sensing pixels, enhancing the biosensor's performance in applications like cell behavior observation and DNA sequencing.
Implementation Method 1
The optical filter may be an organic filter, which is non-angle-sensitive to the incident light and easy to be patterned
Implementation Method 2
The excitation light rejection layer is disposed on the pixelated filter
Implementation Method 3
The photodiodes are disposed in the substrate and correspond to one of the pixels, respectively
Data Source
AI summary
A biosensor is provided. The biosensor includes a substrate, photodiodes, pixelated filters, an excitation light rejection layer and an immobilization layer. The substrate has pixels. The photodiodes are disposed in the substrate and correspond to one of the pixels, respectively. The pixelated filters are disposed on the substrate. The excitation light rejection layer is disposed on the pixelated filter. The immobilization layer is disposed on the excitation light rejection layer.