Rotatable Polarizing Element for Multi-Wavelength Biosensor Filtering
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Solution Overview
Problem
Integrated biosensing devices face challenges in adjusting the transmittance wavelength of embedded filters, limiting their ability to detect multiple fluorescent molecules with different excitation lights, as their fixed transmittance spectra are affected by film thickness and geometry, making it difficult to block various excitation lights effectively.
Innovation Solution
A biosensor and bio detection system that utilize a polarizing element with a different polarization angle than the photodiode, preventing excitation light from reaching the photodiode by converting it to a polarization angle that cannot pass through the polarizing element, allowing a single system to block multiple excitation lights.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If embedded filters with fixed transmittance spectra are used, then the device structure is simple, but the ability to detect multiple fluorescent molecules with different excitation lights is limited
Solution Approach 1:
The patent changes the parameter of light polarization angle to create adjustable filtering capability. By rotating the polarizing element, different excitation wavelengths can be blocked while maintaining a simple device structure with only one filter component.
Solution Approach 2:
The polarizing element serves multiple functions: it blocks excitation lights of various wavelengths by rotation, protects the photodiode from damage, and enables detection of multiple fluorescent molecules with different excitation spectra using a single device structure.
2Adaptability or versatility
If multiple embedded filters are added to block various excitation lights, then the ability to detect multiple fluorescent molecules is improved, but the device complexity increases
Solution Approach 1:
A single polarizing element with rotational capability replaces the need for multiple fixed filters. By rotating the element to different angles, it can selectively block excitation lights of various wavelengths, achieving multi-functionality with a single component.
Solution Approach 2:
The polarizing element is made rotatable, transforming it from a static filter to a dynamic one. This rotational freedom allows the same physical component to adapt its filtering characteristics to match different excitation wavelengths, eliminating the need for multiple fixed filters.
3Adaptability or versatility
If the transmittance wavelength of embedded filters is adjusted, then the detection of multiple fluorescent molecules is improved, but the difficulty of adjusting the filter increases
Solution Approach 1:
Instead of adjusting the transmittance wavelength through complex changes in film thickness or nanostructure geometry, the patent changes the polarization angle parameter by simple rotation. This makes wavelength adjustment easy and intuitive while maintaining effective filtering.
Solution Approach 2:
The rotatable polarizing element provides a dynamic adjustment mechanism that is mechanically simple to operate. The user can easily rotate the element to the required angle to block the desired excitation wavelength, making the adjustment process straightforward and user-friendly.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution enables a single biosensor or bio detection system to effectively block various excitation lights, allowing for the use of multiple excitation lights with different wavelengths, resulting in consistent signal intensities and easier analysis of fluorescent markers.
Implementation Method 1
The excitation light passes through the upper polarizing element, and a polarizing element is disposed on the photodiode. The polarization angle of the upper polarizing element is different from that of the polarizing element. After the excitation light passes through the upper polarizing element, the excitation light is converted to polarize at the same polarization angle as that of the upper polarizing element. Since the excitation light polarizes at a polarization angle that is different from that of the polarization element on the photodiode, the excitation light cannot pass through the polarization element.
Data Source
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Figure 1B
Figure 1C
AI summary
A biosensor is provided. The biosensor includes a substrate, a plurality of photodiodes, a polarizing element and a plurality of reaction sites. The plurality of photodiodes are embedded in the substrate. The polarizing element is disposed on the substrate. The plurality of reaction sites are disposed on the polarizing element.