Biosensor PPG Signal Processing for Arterial Stiffness Detection

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Solution Overview

Problem

Current health monitoring methods are invasive, non-continuous, and time-consuming, requiring multiple instruments for vital sign measurements, and lack real-time, continuous, non-invasive capabilities, especially for detecting vasodilation and related conditions.

Innovation Solution

A non-invasive biosensor system using photoplethysmography (PPG) technology to detect PPG signals at multiple wavelengths, processing these signals to determine vasodilation periods, levels, and arterial stiffness index, enabling continuous and real-time health monitoring.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If traditional health monitoring methods are used, then measurement accuracy can be maintained, but the process becomes invasive and time-consuming

Engineering Contradiction:
Improvedetection accuracyVSAvoidinvasiveness
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The patent replaces mechanical/invasive measurement systems with optical detection systems. Specifically, it uses photoplethysmography (PPG) technology with light sources and photodetectors to measure physiological parameters non-invasively through optical absorption and scattering properties of tissue, eliminating the need for blood draws or direct contact with bodily fluids while maintaining measurement accuracy

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces optical signals as an intermediary to indirectly measure physiological parameters. Instead of directly measuring blood composition or vessel diameter, the system uses light absorption and scattering changes as intermediate indicators that correlate with these parameters, enabling non-invasive detection through optical mediators

Inventive Principle:
Principle #24Intermediary (Mediator)

2Measurement precision

If traditional health monitoring methods are used, then specific vital signs can be measured, but continuous real-time monitoring is not achieved

Engineering Contradiction:
Improvedetection capabilityVSAvoidmonitoring continuity
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent implements continuous monitoring by maintaining constant optical illumination and detection. The PPG system continuously emits light through tissue and detects returning optical signals in real-time, providing uninterrupted measurement of physiological parameters without requiring repeated discrete measurements, thus eliminating time loss between measurements

Inventive Principle:
Principle #20Continuity of useful action

Solution Approach 2:

The patent utilizes the periodic nature of physiological signals (heartbeats, respiratory cycles) to enable continuous monitoring. By detecting periodic variations in optical absorption and scattering that correspond to cardiac and respiratory cycles, the system converts periodic biological actions into continuous measurement data streams

Inventive Principle:
Principle #19Periodic action

3Adaptability or versatility

If multiple instruments are used for vital sign measurements, then comprehensive health data can be obtained, but device complexity increases

Engineering Contradiction:
Improvemonitoring comprehensivenessVSAvoidnumber of instruments
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent creates a multi-functional device where a single PPG system can measure multiple physiological parameters simultaneously. By analyzing different characteristics of the optical signals (amplitude, frequency, phase, waveform morphology), the device can detect heart rate, respiratory rate, blood oxygen saturation, vascular tone, and other parameters, replacing multiple specialized instruments with one universal device

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent combines multiple measurement functions into a single integrated optical detection system. Rather than using separate devices for pulse oximetry, respiratory monitoring, and vascular assessment, the system merges these functions by detecting all parameters through the same PPG optical signals, thereby reducing overall system complexity while maintaining comprehensive monitoring capability

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables continuous, non-invasive, and real-time monitoring of health conditions, improving detection of vasodilation and related arterial health parameters, enhancing the accuracy of vital sign measurements and previously difficult-to-measure biological parameters like blood gas analysis and vascular health.

Implementation Method 1

an optical sensor or photoplethysmography (PPG) circuit configured to transmit light at a plurality of wavelengths directed at skin tissue of a user

Methodology Applied
Scientific EffectPhotoplethysmography: Absorption (EM radiation)

Data Source

PatentUS11980741B2System and method of a biosensor for detection of vasodilation
Publication Date: 2024.05.14 TRILINEAR BIOVENTURES LLC
  • US11980741B2 patent drawing
  • US11980741B2 patent drawing
  • US11980741B2 patent drawing

AI summary

An optical circuit detects PPG signals reflected from skin tissue at one or more different wavelengths. A processing circuit integrated in the biosensor or in communication with the biosensor processes the PPG signals to obtain a period of vasodilation, a level of vasodilation and rate of change of the level of vasodilation. The processing circuit compares the level of vasodilation to a normal range and determines an arterial stiffness index using the comparison and the rate of change of the level of vasodilation.