Biosensor Sampling With Return Flow for Cleaning-Solution Removal
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Solution Overview
Problem
The mixing of cleaning solution with the sample during the sampling process in a biosensor system leads to potential contamination and inaccurate measurements, as the cleaning solution remains in the introduction path and is washed away by the sample.
Innovation Solution
A sampling method that includes a sampling step followed by a cleaning step, where the sample is introduced twice, with a returning step to fill the vicinity of the connection portion with the sample, ensuring the cleaning solution is removed before the sample contacts the biosensor, thereby preventing mixing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the cleaning solution is introduced into the sampling flow path to remove adhering sample from the biosensor, then the biosensor is cleaned effectively, but the cleaning solution remains in the introduction path and may mix with the subsequent sample
Solution Approach 1:
The patent applies preliminary action by performing a returning step before the next sampling measurement. After the cleaning step, the sample is caused to flow into the introduction path from the connection portion to replace the cleaning solution that remains there. This preliminary replacement action prevents the cleaning solution from mixing with the sample during the subsequent sampling step, thus resolving the contradiction between effective cleaning and sample contamination prevention
2Productivity
If the sample is introduced directly through the sampling flow path without returning, then the sampling process is simple and fast, but the cleaning solution in the introduction path mixes with the sample causing contamination
Solution Approach 1:
The returning step serves as a preliminary action that quickly replaces the cleaning solution in the introduction path with sample before the actual measurement begins. This brief preliminary flow ensures that when the sample is subsequently introduced for measurement, no cleaning solution mixing occurs, thus maintaining both sampling speed and measurement accuracy
Data Source
AI summary
A sampling method includes a sampling step and a cleaning step. The sampling step includes a first sample introduction step of introducing a first sample from a first cell culturing device to a more downstream side than a first connection portion in a sampling flow path, a first returning step of causing the first sample in the sampling flow path to flow into an introduction path from the first connection portion after the first sample introduction step, and a first flowing step of bringing the first sample into contact with a second sensor after the first returning step.