Electrochemical Biosensor Sealing Film and Flow Cell Design
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Solution Overview
Problem
Existing electrochemical biosensors face challenges in reliable thermal and fluidic contacting, complex manufacturing, and spreading of recognition molecules during coating, leading to inaccurate measurements and handling issues.
Innovation Solution
A device with a base plate and sensor array using a sealing film instead of rings for fluid-tight sealing, trenches around sensors to prevent liquid spreading, and a self-adhesive film for easy assembly, ensuring reliable thermal control and laminar flow.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If hydrophobic coatings are used to prevent spotting solution spreading, then specific coating reliability is improved, but device complexity and manufacturing elaborateness increase
Solution Approach 1:
The invention extracts the coating aid function from complex hydrophobic coatings and implements it through simple geometric structures (trenches or elevations) that physically contain the spotting solution, thereby achieving reliable specific coating without elaborate coatings
Solution Approach 2:
The patent uses a sealing film with recesses that acts as a flexible coating aid, providing solution containment through geometric design rather than chemical hydrophobicity, simplifying both device structure and manufacturing
2Manufacturing precision
If indentations with coating aids are provided to prevent solution spreading, then specific coating is improved, but air bubble formation increases leading to measurement errors
Solution Approach 1:
The invention applies coating aids only in the immediate vicinity of each electrode (local trenches or elevations) rather than across the entire sensor surface, preventing solution spreading while maintaining a largely flat sensor surface that minimizes air bubble formation during measurement
3Manufacturing precision
If plastic rings or structured films are fastened around electrodes to create indentations, then solution spreading is prevented, but device complexity and assembly elaborateness increase
Solution Approach 1:
The invention merges the coating aid function with the base plate structure itself through integrated trenches or elevations, eliminating the need for separate plastic rings or structured films, thereby simplifying both manufacturing and assembly
Solution Approach 2:
The patent employs a flexible sealing film with built-in recesses that combines solution containment and sealing functions in a single component, eliminating multiple parts and simplifying assembly while maintaining effective solution containment
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables simple, cost-effective production and reliable specific studies with reduced parts, preventing liquid spreading and bubble formation, thus improving measurement accuracy and handling efficiency.
Implementation Method 1
The coating of the base plate is configured such that it covers regions of the base plate adjacent to the sensors and substantially prevents wetting and spreading of liquids applied onto the sensor array
Implementation Method 2
a sealing film (2) having at least one recess (11) through which, in mechanical combination with the base plate (1) and/or the coating of the base plate, a flow cell is formed over the sensor array (4)
Data Source
AI summary
A device is intended to electrochemically measure biochemical reactions and includes a base plate, a sensor array situated on the latter, a coating of the base plate, and a sealing film with at least one recess. The recess is mechanically connected to the base plate and/or to the coating of the base plate and forms a flow cell above the sensor array. An inlet and an outlet of the flow cell are in the form of continuous recesses in the base plate. The active surfaces of the sensors are free of the coating and regions of the base plate adjacent to the sensors are covered by the coating.