Biosensor Strip Hydrophilic Layer Siphoning Design
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Solution Overview
Problem
Conventional biosensor strips lack an effective design for facilitating the rapid flow of specimens from one flow channel to another, leading to insufficient specimen interaction with enzymes, which compromises measurement accuracy.
Innovation Solution
A biosensor strip design featuring two hydrophilic layers on either side of a flow channel, with a hydrophilic material doped into the enzyme layer, enhances specimen siphoning and mixing with enzymes, ensuring accurate measurements by facilitating even distribution and electrochemical reactions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If the sample area is not designed specifically for assisting specimen flow, then the biosensor strip structure remains simple, but insufficient specimen reaches the enzyme layer severely damaging measurement accuracy
Solution Approach 1:
The sample area is segmented into multiple functional zones including a first sample area with a first flow channel, a second sample area with a second flow channel, and a mixing area. This segmentation guides the specimen through distinct pathways ensuring complete delivery to the enzyme layer while maintaining a relatively simple overall structure.
Solution Approach 2:
A hydrophilic material is introduced as an intermediary substance in the mixing area to facilitate specimen-enzyme interaction. This intermediary mechanism enhances measurement accuracy by ensuring complete mixing without requiring complex flow control structures.
2Reliability
If conventional sample area design is used, then manufacturing remains simple, but specimen flow is insufficient leading to poor enzyme-substrate interaction
Solution Approach 1:
The sample area is designed with different local qualities: the first and second sample areas have specific flow channel configurations optimized for specimen delivery, while the mixing area has a different configuration optimized for specimen-enzyme interaction. This localized optimization ensures reliable specimen interaction while maintaining manufacturing feasibility through standard printing processes.
3Speed
If specimen flow is not accelerated, then the biosensor strip structure remains simple, but insufficient specimen reaches the enzyme layer in timely manner
Solution Approach 1:
The flow channels are designed to transition from a first dimension (initial specimen introduction) to a second dimension (mixed specimen flow) in the mixing area. This dimensional transition accelerates specimen flow speed by utilizing the geometric configuration of the flow channels to guide and accelerate the specimen toward the enzyme layer.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The improved sample area design enables rapid and complete specimen-enzyme interaction, enhancing measurement accuracy and reliability of biological instruments.
Implementation Method 1
a first hydrophilic layer, disposed on a surface of the carbon layer through the spacing of a first insulated layer, having a reaction zone and a first hydrophilic guiding area formed thereon
Implementation Method 2
an enzyme layer, disposed on the reaction zone of the first hydrophilic layer, having a hydrophilic material doped therein
Data Source
AI summary
A biosensor strip with improved sample area design is disclosed, in which a specimen flowing in a flow channel is siphoned into another flow channel which has two hydrophilic layers attached to two respective sides of the same for enhancing the siphoning of the specimen. In an embodiment, by the doping of a hydrophilic material into an enzyme layer of the biosensor strip, the specimen that is being siphoning rapidly is able to mixed with the enzyme fully so as to enhance the measurement accuracy of a biological instrument using the biosensor strip.