Biosensor Tissue Identification Using Pulse Voltage Detection
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Solution Overview
Problem
During surgical operations, especially for tumor or cancer treatment, accurate identification of tumor tissue versus healthy tissue is challenging, leading to reduced resection accuracy, potential disease recurrence, and increased surgical risks due to difficulties in distinguishing between tissues and blood vessels in real-time.
Innovation Solution
A tissue identification method utilizing a biosensor with a transistor and response electrode, applying a pulse voltage to generate a detection current, and processing it to obtain sensing indicators for effective and rapid tissue differentiation, employing high electron mobility transistors for improved electrical properties and compatibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional surgical methods are used without advanced detection equipment, then the device complexity is low, but the measurement precision of tissue identification is insufficient
Solution Approach 1:
The biosensor is divided into functionally independent modules: a transistor component for electrical signal generation and a response electrode component for tissue interaction. This segmentation allows each module to be optimized independently while maintaining overall system precision without excessive complexity.
Solution Approach 2:
The biosensor integrates multiple functions into a single device: tissue identification, electrical signal application, and current measurement. This multi-functionality improves measurement precision while avoiding the complexity of multiple separate devices.
2Measurement precision
If pathological examination is performed to accurately identify tissue type, then the measurement precision is high, but the loss of time is significant
Solution Approach 1:
The biosensor performs preliminary electrical characterization of tissue by applying pulse voltages and measuring current responses before surgical resection. This preliminary action provides immediate tissue identification guidance, eliminating the need for time-consuming post-resection pathological examination while maintaining high accuracy.
Solution Approach 2:
The patent replaces the mechanical/pathological examination system with an electrical detection system. By using electrical signals to probe tissue properties and measure current responses, the system achieves rapid real-time identification without the time delay inherent in traditional pathological processing.
3Measurement precision
If surgeons rely on clinical experience to identify tissue, then the device complexity is low, but the measurement precision and reliability are insufficient
Solution Approach 1:
The biosensor provides real-time feedback to surgeons by measuring electrical current responses from different tissue types and translating them into identifiable patterns. This objective electrical feedback supplements and enhances subjective clinical experience, improving measurement precision without requiring complex additional equipment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables effective and rapid tissue identification, reducing the risk of miscutting blood vessels and improving surgical efficiency and safety by providing real-time differentiation between various tissues, thereby enhancing tumor resection accuracy.
Implementation Method 1
applying a pulse voltage which has a tunable pulse width and a tunable pulse height to the response electrode, resulting in a voltage difference between the response electrode and the gate terminal of the transistor, and measuring and calculating a detection current which is generated from the transistor
Data Source
AI summary
A tissue identification method including a preparation step and a detection step is provided. The preparation step includes preparing a biosensor which includes a transistor and a response electrode. The response electrode is spaced apart from the transistor relative to a gate terminal of the transistor. The detection step includes disposing a biological tissue sample to be identified on the response electrode, applying a pulse voltage that has a tunable pulse width and a tunable pulse height to the response electrode, resulting in a voltage difference between the response electrode and the gate terminal of the transistor, and measuring and calculating a detection current which is generated from the transistor in the pulse width, so as to obtain a first sensing indicator. In addition, a biosensor for tissue identification is also provided.