Biosensor Detection Unit for Tumor Marker Analysis
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Solution Overview
Problem
Current methods for detecting tumor and cancer markers are complex, labor-intensive, time-consuming, and costly, often limited to qualitative determination, and lack automation, making timely and portable biosensory tissue typing for urogenital tract diseases challenging.
Innovation Solution
A biosensor detection unit with specific capture molecules immobilized on a carrier, generating electrical measurement signals upon interaction with target molecules, enabling qualitative and quantitative analysis of marker profiles in biological samples, and allowing for automated or semi-continuous detection of tumor or cancer-specific markers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional detection methods (ELISA, Western blotting, FISH) are used to detect tumor markers, then detection accuracy can be achieved, but the processes become technically complex, labor-intensive, and time-consuming
Solution Approach 1:
The patent combines multiple detection functions into a single integrated biosensor device that can detect multiple tumor markers simultaneously. The biosensor integrates sample processing, detection, and analysis functions that were previously distributed across multiple separate techniques (ELISA, Western blotting, FISH), thereby reducing process complexity while maintaining detection accuracy.
Solution Approach 2:
The biosensor is designed as a universal detection platform capable of detecting various tumor markers (proteins, DNA, RNA) using a single device. This multi-functional approach replaces the need for multiple specialized techniques, reducing both device complexity and operational complexity while preserving measurement precision across different marker types.
2Measurement precision
If conventional detection methods are used, then quantitative determination can be achieved, but automation is not possible or difficult
Solution Approach 1:
The biosensor incorporates self-service features including automated sample processing, automatic detection, and integrated data analysis. The device performs quantitative determination of tumor markers without requiring manual intervention for each step, enabling full automation while maintaining measurement precision. The system automatically processes samples, detects markers, and generates results without human operation.
3Measurement precision
If comprehensive marker analysis is performed to create disease-specific profiles, then diagnostic accuracy improves, but time consumption and cost increase
Solution Approach 1:
The biosensor enables continuous and simultaneous detection of multiple tumor markers in a single workflow. Instead of performing sequential analyses for different markers (which would be time-consuming and costly), the device continuously detects all relevant markers in parallel, maintaining high diagnostic accuracy while significantly reducing time consumption and operational costs.
4Speed
If portable and automated biosensory tissue typing is implemented, then timely detection is achieved, but integration of detection components and sensors becomes complex
Solution Approach 1:
The patent integrates all detection components, sensors, and processing functions into a single compact biosensor unit. This merging approach enables portable and automated biosensory tissue typing while achieving timely detection. The integration combines sample processing chambers, detection electrodes, and data processing units into one cohesive device that can be deployed portably without sacrificing detection speed or functionality.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Facilitates rapid identification of tissue-typical markers, enabling timely and portable detection of urogenital tract diseases, supporting intraoperative therapy optimization and creation of disease-specific profiles for a reference database, improving diagnostic accuracy and therapeutic decision-making.
Implementation Method 1
a measurement signal, in particular an electrical measurement signal, is generated as a result of the interaction between the capture molecule on the one hand and the target molecule on the other
Data Source
AI summary
The invention relates to a detection unit (1), in particular a biosensor, for generating a measurement signal, in particular an electrical measurement signal, on account of interaction between a capture molecule (2), on the one hand, and a target molecule (3), on the other hand, wherein the detection unit (1) has a carrier (4), wherein a measuring device (5) which is used to detect the interaction between the capture molecule (2), on the one hand, and the target molecule (3), on the other hand, and to generate a measurement signal, in particular an electrical measurement signal, is arranged on the carrier (4), wherein a capture molecule (2) is immobilized on the carrier (4) and/or on the measuring device (5), preferably on the measuring device (5), wherein the capture molecule (2) is suitable for interacting, in a specific manner, with a target molecule (3) which is characteristic of the occurrence and/or presence of illnesses from the group of oncoses, in particular carcinomataceous disorders and inflammatory disorders of the urogenital tract.