Biosensor Voltage Timing for Interference Correction
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Solution Overview
Problem
Conventional measurement systems using redox reactions struggle to accurately measure the concentration of target substances in liquid samples due to interference from substances like ascorbic acid and uric acid, as their oxidizable potential varies, leading to inconsistent current values and inaccurate measurements.
Innovation Solution
A measurement device and method that employs a biosensor with first and second electrode systems, applying different voltage levels at various times to the second electrode system to detect interfering substances and correct the concentration of the target substance based on changes in current values, allowing for precise measurement by accounting for the unique redox potential of each interfering substance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a single voltage is applied to detect target substance concentration, then the measurement process is simple, but interfering substances cause inaccurate measurements
Solution Approach 1:
The patent divides the measurement process into multiple voltage application steps: a first voltage application for detecting the target substance and a second voltage application for detecting interfering substances. This segmentation allows separate detection of different components, improving measurement accuracy by isolating the interference effect from the target substance measurement.
Solution Approach 2:
The patent employs periodic voltage applications with different voltage levels at different timings. The voltage is applied periodically in cycles: first voltage for target detection, then second voltage for interference detection. This periodic action enables systematic separation and measurement of different substances' contributions to the current signal.
2Measurement precision
If multiple voltage levels are applied to account for different interfering substances, then measurement accuracy improves, but the measurement process becomes more complex
Solution Approach 1:
The patent performs preliminary detection of interfering substances by applying a second voltage before or during the target substance measurement. By detecting the interference effect in advance, the system can compensate for it in the final concentration calculation, improving accuracy without requiring separate lengthy measurement processes.
Solution Approach 2:
The patent merges the detection of target substances and interfering substances into a single integrated measurement process. Both detections occur during the same measurement cycle using different voltage levels, allowing simultaneous acquisition of both data sets and eliminating the need for separate measurement sessions.
3Measurement precision
If interfering substances are detected and corrected for, then concentration measurement accuracy improves, but the device structure becomes more complex
Solution Approach 1:
The patent makes the existing electrode system multi-functional by using it for both target substance detection and interfering substance detection through different voltage applications. The same electrodes serve dual purposes, eliminating the need for additional dedicated detection electrodes for interfering substances and maintaining structural simplicity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables more accurate measurement of target substance concentrations by effectively accounting for the varying effects of interfering substances, reducing measurement discrepancies and improving the reliability of concentration readings.
Implementation Method 1
a biosensor that has an insulated substrate, a working electrode and a counter electrode formed on the insulated substrate, a reaction layer provided on the working electrode and the counter electrode, and the reaction layer contains an oxidoreductase and an electron mediator
Implementation Method 2
the current value may fluctuate depending on the presence of interfering substances such as compounds that are readily oxidized (such as ascorbic acid and uric acid)
Data Source
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AI summary
A first measurement device is a measurement device for measuring the concentration of a target substance in a sample deposited on a biosensor, and more particularly is constituted such that at least two kinds of voltage of mutually different levels are applied at mutually different timings to the electrode system of the biosensor, and the concentration is corrected on the basis of the amount of change in the current value.