Biosensor Waveguide Parallel Detection
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Solution Overview
Problem
Conventional biosensor chips based on whispering gallery modes require a long time for measurement, which limits their efficiency in detecting biological particles.
Innovation Solution
A biosensor device with a waveguide and multiple sensor active structures, such as microspheres, that can simultaneously detect different biological particles by modifying electromagnetic radiation transmission properties, allowing for parallel detection without crosstalk through spatially separated optical fibers, enabling fast and accurate analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional biosensor chips based on whispering gallery modes are used, then sensitivity to biological particles is achieved, but measurement time becomes comparatively long
Solution Approach 1:
The biosensor chip is divided into multiple independently addressable sensor regions, each capable of detecting different biological particles. This segmentation allows parallel processing of multiple detection tasks simultaneously, reducing total measurement time while maintaining high sensitivity through dedicated sensor regions for each target analyte.
Solution Approach 2:
The invention transitions from sequential measurement approaches to a multi-dimensional parallel detection architecture by adding spatial dimensions (multiple sensor regions) and functional dimensions (different capture molecules for different particles). This dimensional expansion enables simultaneous detection of multiple biological particles, dramatically reducing measurement time without sacrificing detection sensitivity.
2Productivity
If multiple sensor active structures are arranged at the electromagnetic radiation transmitting member, then simultaneous detection of different biological particles is enabled, but device complexity increases
Solution Approach 1:
The electromagnetic radiation transmitting member serves multiple functions: it acts as both the waveguide for electromagnetic radiation and as the mounting substrate for multiple sensor active structures. This multi-functionality reduces device complexity by eliminating separate structural components while enabling simultaneous detection of different biological particles through the integrated sensor array.
Solution Approach 2:
Multiple sensor active structures are merged onto a single electromagnetic radiation transmitting member, combining multiple detection functions into one integrated platform. This merging approach reduces the number of separate components and simplifies the overall device architecture while maintaining the capability for parallel detection of multiple biological particles.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables rapid and accurate detection of biological particles, reducing measurement time and simplifying the detection process, while avoiding the need for labels and minimizing PCR amplification, thus improving sensitivity and cost-effectiveness.
Implementation Method 1
conventional biosensor chips based on whispering gallery modes may require a measurement that takes a comparatively long amount of time
Implementation Method 2
hybridization events between capture molecules immobilized on the microspheres and complementary biomolecules
Implementation Method 3
simultaneous measurement of multiple separate electromagnetic radiation beams propagating without crosstalk through the electromagnetic radiation transmitting member
Data Source
AI summary
A biosensor device (100) for detecting biological particles, the biosensor device (100) comprising an electromagnetic radiation transmitting member (102) adapted for transmitting electromagnetic radiation and a plurality of sensor active structures (104) arranged at the electromagnetic radiation transmitting member (102), wherein each of the plurality of sensor active structures (104) is sensitive to specific biological particles and is adapted to modify electromagnetic radiation transmission properties of the electromagnetic radiation transmitting member (102) in the event of the presence of the respective biological particles, and wherein the electromagnetic radiation transmitting member (102) is adapted for a simultaneous detection of different biological particles at different ones of the plurality of sensor active structures (104).