Biosorbable Oxygen-Generating Wound Dressing
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Solution Overview
Problem
Current wound treatment devices for delivering oxygen to compromised tissues lack biosorbability, wet strength, and practicality for use in surgical incisions, as they are either non-biosorbable or require toxic cross-linking agents, limiting their effectiveness and safety for internal use.
Innovation Solution
A biosorbable oxygen-delivery wound treatment device featuring a cross-linked biosorbable polymer network that forms gas-permeable, elastic closed cells, using biocompatible materials like hyaluronic acid, gelatin, and propylene glycol alginate, with hydrogen peroxide generating oxygen within the matrix, and optionally incorporating active agents for enhanced healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If a closed cell oxygen-containing foam dressing based on polyacrylamide is used, then oxygen delivery capacity is improved, but biosorbability is lost making it unsuitable for internal use
Solution Approach 1:
The patent changes the chemical composition parameters of the foam matrix from synthetic polyacrylamide to biosorbable polymers including gelatin, collagen, chitosan, and alginate. This parameter change maintains the closed-cell foam structure and oxygen delivery capability while adding biosorbability for internal surgical use.
Solution Approach 2:
The patent creates a composite foam material combining multiple biosorbable polymers (gelatin, collagen, chitosan, alginate) with cross-linking agents to achieve both structural integrity and biosorbability. The composite structure incorporates oxygen-generating peroxide compounds within the foam matrix while maintaining biocompatibility.
2Adaptability or versatility
If gelatin is used to make a biosorbable oxygen foam dressing, then biosorbability is achieved, but wet strength is insufficient making handling difficult
Solution Approach 1:
The patent introduces cross-linking agents as intermediaries that form chemical bonds between gelatin and collagen molecules. These cross-links act as structural bridges that maintain wet strength while preserving biosorbability, allowing the foam to handle properly in wet wound environments.
Solution Approach 2:
The patent combines gelatin with collagen and other structural polymers to create a composite matrix where different materials complement each other's properties. The multi-component composite provides both biosorbability from the natural polymers and adequate wet strength through synergistic interactions and cross-linking.
3Strength
If cross-linking agents are used to improve wet strength, then handling becomes easier, but toxic cross-linking agents cannot be used for internal surgery
Solution Approach 1:
The patent employs biocompatible, biodegradable cross-linking agents that are safe for internal use and will be metabolized or excreted by the body. These temporary cross-links provide necessary strength during handling and initial wound contact, then gradually degrade as the wound heals, eliminating long-term toxicity concerns.
Solution Approach 2:
The patent changes the chemical nature of cross-linking agents from permanent, potentially toxic synthetic agents to temporary, biocompatible natural agents. The cross-linking parameters are optimized to provide adequate strength during use while ensuring complete biodegradation, transforming the cross-linking function from permanent structural reinforcement to temporary handling aid.
4Ease of operation
If a biosorbable foam is designed for internal surgical incisions, then the need for dressing removal is eliminated, but adequate wet strength for handling is required
Solution Approach 1:
The patent applies cross-linking treatment during the manufacturing process, before the foam is applied to the wound. This preliminary cross-linking establishes the necessary wet strength and structural integrity during handling and application, while the cross-links remain biodegradable for safe internal use during the healing process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device provides sustained oxygen delivery to wounds, promoting healing while being resorbable, eliminating the need for dressing removal and ensuring safety with non-toxic components, thus enhancing wound care by accelerating healing and reducing complications.
Implementation Method 1
A plurality of gas-permeable, elastic, closed cells are defined by the cross-linked biosorbable polymer network and are produced from a reaction between a catalyst and hydrogen peroxide
Data Source
AI summary
A biosorbable oxygen-delivery wound treatment device that includes a biosorbable matrix for delivering oxygen. The biosorbable matrix includes a water swellable, cross-linked biosorbable polymer network. A plurality of gas-permeable, elastic, closed cells is defined by the cross-linked biosorbable polymer network. According to the invention, these closed cells may be produced from a reaction between a catalyst and a second reactant. Deliverable oxygen is contained within the elastic closed cells such that when the device is used to treat a wound, oxygen is delivered from the closed cells. A process for making a biosorbable oxygen-delivery wound treatment device that includes a biosorbable matrix for delivering oxygen as well as a method of using an oxygen-delivery wound treatment device is disclosed.