Bi-Peptide Anchoring Growth Factors to Extracellular Matrix

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Solution Overview

Problem

Current treatments for musculoskeletal injuries, such as ACL tears, face challenges in achieving complete healing due to poor tissue healing capacity, leading to prolonged recovery times and potential re-injury, with existing surgical interventions often resulting in scarring, stiffness, and restricted joint motion.

Innovation Solution

A bi-peptide comprising a growth factor-binding peptide linked to an extracellular matrix protein-binding peptide, which can be attached to a polymer, is introduced to target and capture growth factors, enhancing tissue healing by promoting regeneration and repair.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Strength

If surgical intervention is performed to stabilize and restore joint movement, then joint stability is improved, but complete healing is difficult to achieve leading to scarring and stiffness

Engineering Contradiction:

Improvejoint stabilityVSAvoidcomplete healing

Core Design Contradiction:

StrengthVSReliability

Solution Approach 1:

The bi-peptide acts as an intermediary molecule that bridges growth factors and extracellular matrix proteins. It contains a growth factor-binding domain that captures growth factors and an ECM-binding domain that anchors the complex to the extracellular matrix, facilitating targeted delivery and sustained release of growth factors at the injury site to promote complete tissue healing

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention creates a composite functional structure by combining two distinct peptide sequences with different binding specificities into a single bi-peptide molecule. This composite structure enables simultaneous interaction with both growth factors and extracellular matrix proteins, achieving multiple therapeutic functions in one agent

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If surgical intervention is performed to restore joint movement, then normal movement is restored, but recovery time is prolonged between 9 to 12 months

Engineering Contradiction:

Improvejoint movement restorationVSAvoidrecovery period

Core Design Contradiction:

Ease of operationVSLoss of time

Solution Approach 1:

The bi-peptide is applied at the time of surgery to preliminarily enhance the healing process by capturing and delivering growth factors that stimulate tissue regeneration. This preliminary action accelerates the natural healing process, reducing the overall recovery time while maintaining joint movement restoration

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The invention changes the temporal parameter of the healing process by introducing a sustained-release mechanism through the bi-peptide-ECM complex. This extends the presence and activity of growth factors at the injury site over time, accelerating tissue regeneration and shortening the recovery period

Inventive Principle:

Principle #35Parameter changes

3Reliability

If growth factors are delivered to promote tissue regeneration, then tissue healing is enhanced, but sustained concentration at the injury site is difficult to maintain

Engineering Contradiction:

Improvetissue regenerationVSAvoidsustained concentration

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The bi-peptide serves as a mediator that binds growth factors and transports them to the ECM, where they are retained. This intermediary mechanism protects growth factors from degradation and prevents their rapid clearance, maintaining sustained concentrations at the injury site

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention transitions growth factor delivery from a transient systemic or local application to a anchored, matrix-bound state. By binding growth factors to the ECM through the bi-peptide, the system creates a reservoir that releases growth factors slowly over time, extending their duration of action

Inventive Principle:

Principle #17Another dimension (Dimensionality change)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The bi-peptide effectively captures and delivers growth factors to the injury site, enhancing tissue regeneration, reducing recovery time, and improving the healing process by providing a sustained concentration of bioactive factors, thereby improving the efficiency and effectiveness of tissue repair.

Implementation Method 1

peptide 1 has an affinity to a growth factor or a growth factor receptor

Methodology Applied

Scientific EffectAffinity binding: Absorption (physical)

Implementation Method 2

peptide 2 has an affinity for an extracellular matrix protein

Methodology Applied

Scientific EffectAffinity binding: Absorption (physical)

Data Source

PatentUS20230312685A1Bi-Peptide with Affinity to Extracellular Matrix Proteins or Cells and to Growth Factors for Tissue Healing and Regeneration

Publication Date: 2023.10.05 MAYO FOUNDATION FOR MEDICAL EDUCATION & RESEARCH

AI summary

The present invention includes a bi-peptide, a method of making, and a method using the bi-peptide to treat a disease or condition, wherein the bi-peptide comprises the formula: peptide 1n-linkern-peptide 2n, or peptide 2n-linkern-peptide 1n wherein peptide 1 has an affinity to a growth factor or a growth factor receptor, wherein peptide 2 has an affinity for an extracellular matrix protein, and wherein the linker is a chemical or peptide linker, and n is one or more.