Biphasic Calcium Phosphate Work Time Control via Ca/P Ratio
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Solution Overview
Problem
Current methods for producing biphasic self-setting calcium phosphate (SSCP) materials struggle with controlling the work time for shape-forming, leading to either excessively short or long setting times, which affects their applicability in bone grafting and dental materials, and result in materials that are not adequately compatible or stable within the body.
Innovation Solution
A method involving a biphasic SSCP powder portion comprising TTCP and α-TCP, kneaded with a biphasic SSCP liquid portion containing a phosphoric acid solution and calcium components like Ca(OH)2, CaO, or CaCO3, at temperatures between 10 to 40°C, to adjust the work time from 10 seconds to 600 seconds, ensuring shape formability and maintainability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional methods are used to produce biphasic SSCP materials, then the materials can be formed, but the work time for shape-forming cannot be controlled, resulting in excessively short or long setting times
Solution Approach 1:
The patent controls work time by adjusting the Ca/P ratio parameter of the raw material powder to 1.30 to 1.45, and by controlling the pH value of the liquid agent to be 4.0 to 6.0. These parameter changes enable precise control over the setting time, transforming it from an uncontrollable variable to a可调 parameter that can be optimized for specific applications.
Solution Approach 2:
The patent introduces dynamic control mechanisms by adjusting the composition ratios of TTCP and α-TCP within the biphasic SSCP powder portion, and by modifying the liquid agent composition including organic acids, inorganic acids, and their salts. This dynamic adjustment of compositional parameters allows the work time to be tailored according to specific application requirements.
2Productivity
If the setting time is reduced for faster application, then productivity improves, but the materials may not be adequately compatible or stable within the body
Solution Approach 1:
The patent establishes specific parameter ranges: Ca/P ratio of 1.30 to 1.45, pH value of 4.0 to 6.0 for the liquid agent, and specific composition ratios of TTCP and α-TCP. These parameter changes ensure that the material sets within an optimal time frame while maintaining biocompatibility and stability in the body, preventing both premature setting and excessive setting times that could compromise reliability.
Solution Approach 2:
The patent uses a composite material system consisting of biphasic SSCP powder portion (TTCP and α-TCP) combined with a liquid agent containing organic acids, inorganic acids, and their salts. This composite approach allows the material to achieve both rapid setting and long-term stability, as the different components work synergistically to control setting kinetics while maintaining biocompatibility.
3Manufacturing precision
If the work time is extended to allow proper shaping, then shape formability improves, but the setting time becomes excessively long affecting clinical efficiency
Solution Approach 1:
The patent optimizes the Ca/P ratio to 1.30 to 1.45 and controls the liquid agent pH to 4.0 to 6.0, creating an optimal chemical environment that provides sufficient work time for shape formation (typically 5-30 minutes) while ensuring complete setting occurs within a clinically acceptable timeframe. This parameter optimization balances shape formability with time efficiency.
Solution Approach 2:
The setting process occurs in distinct phases: an initial working phase where the material remains moldable for shape formation, followed by a setting phase where hardening occurs. The patent controls the transition between these phases by adjusting composition parameters, ensuring the working phase is long enough for proper shaping but transitions to setting quickly enough to maintain clinical efficiency.
4Manufacturing precision
If the material composition is adjusted to control setting time, then work time control improves, but the complexity of the manufacturing process increases
Solution Approach 1:
The patent controls work time by adjusting compositional parameters (Ca/P ratio, pH value, component ratios) rather than introducing complex manufacturing equipment or multi-step processes. This approach maintains manufacturing simplicity while achieving precise work time control through chemical composition optimization, avoiding unnecessary process complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for controlled work time and setting of biphasic SSCP materials, enhancing their biocompatibility, safety, and stability, enabling effective bone grafting and dental applications by maintaining shape and promoting bone replacement without dissolution in the body fluid.
Implementation Method 1
a biphasic SSCP liquid portion containing a phosphoric acid solution and calcium components like Ca(OH)2, CaO, or CaCO3
Implementation Method 2
biphasic self-setting calcium phosphate (SSCP)... low-temperature hydroxyapatite produced from biphasic self-setting calcium phosphate
Implementation Method 3
produced by a method involving a biphasic SSCP powder portion comprising TTCP and α-TCP
Data Source
AI summary
Biphasic self-setting calcium phosphate (SSCP) used for bone graft material and dental material applications having shape formability, shape retentivity, and bone replacement properties in addition to biocompatibility, safety, non-infectiousness, and absence of outflow, wherein the work time for forming the shape of a kneaded material obtained by kneading biphasic SSCP powder and biphasic SSCP liquid is controlled. A method for controlling the work time for forming the shape of biphasic SSCP in which the moldable work time from the start of kneading to the setting of the kneaded material is adjusted to within a range of from 10 seconds to 600 seconds by kneading a biphasic SSCP powder and biphasic SSCP liquid, the biphasic SSCP powder comprising tetracalcium phosphate and α-tricalcium phosphate and the biphasic SSCP liquid comprising a phosphoric acid aqueous solution containing a calcium component.