Biphasic Topical Product Oxygen Barrier
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Solution Overview
Problem
Topical products containing trichloroacetic acid face issues with oxidation upon exposure to oxygen, leading to degradation and the formation of harmful substances, which compromises their safety and effectiveness, and existing stabilization methods do not adequately address these concerns.
Innovation Solution
A biphasic topical product with a hydrophilic and lipophilic phase, where the lipophilic phase floats above the hydrophilic phase, creating a physical barrier that prevents contact with oxygen and thus oxidation of trichloroacetic acid, eliminating the need for stabilizers and preservatives while maintaining product stability and safety.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If trichloroacetic acid is used in topical products, then exfoliating activity is achieved, but oxidation occurs upon contact with oxygen leading to degradation and formation of harmful substances
Solution Approach 1:
The product is divided into two separate phases: a hydrophilic phase containing trichloroacetic acid and a lipophilic phase that forms a protective barrier. This segmentation prevents direct contact between the acid and oxygen while maintaining the acid's exfoliating activity in the hydrophilic phase.
Solution Approach 2:
The lipophilic phase creates an oxygen-excluded environment above the hydrophilic phase, effectively providing an inert barrier that prevents oxidation of trichloroacetic acid. This physical barrier isolates the acid from atmospheric oxygen without requiring chemical stabilizers.
2Reliability
If chemical stabilizing agents are added to prevent oxidation, then stability is improved, but the composition becomes more complex and may affect skin tolerability
Solution Approach 1:
Instead of adding chemical stabilizers to the trichloroacetic acid solution, the invention extracts the protection function to a separate lipophilic phase. This physical barrier approach eliminates the need for chemical stabilizing agents, simplifying the overall composition while maintaining stability.
Solution Approach 2:
The lipophilic phase acts as an intermediary barrier between the trichloroacetic acid and oxygen. This mediator prevents direct interaction between the acid and oxidizing agents, providing stability without requiring chemical stabilizers that could complicate the formulation or affect skin tolerability.
3Ease of operation
If monophasic hydrogels are used, then application is simplified, but oxidation occurs leading to loss of activity and safety
Solution Approach 1:
The product is divided into two separate phases: a hydrophilic phase containing trichloroacetic acid and a lipophilic phase that forms a protective barrier. This segmentation prevents direct contact between the acid and oxygen while maintaining the acid's exfoliating activity in the hydrophilic phase.
Solution Approach 2:
The lipophilic phase creates an oxygen-excluded environment above the hydrophilic phase, effectively providing an inert barrier that prevents oxidation of trichloroacetic acid. This physical barrier isolates the acid from atmospheric oxygen without requiring chemical stabilizers.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biphasic product effectively prevents oxidation of trichloroacetic acid, maintaining its stability and safety for extended periods without the use of stabilizers or preservatives, ensuring skin tolerance and prolonged shelf life, while providing a natural and effective skin treatment.
Implementation Method 1
the lipophilic phase floats above the hydrophilic phase, so that the latter does not come into direct contact with the oxygen present in the atmosphere
Implementation Method 2
prevents contact with oxygen and thus oxidation of trichloroacetic acid
Data Source
AI summary
A biphasic topical product comprising a hydrophilic phase and a lipophilic phase floating on said hydrophilic phase. A method for preparing biphasic topical products.