Biphenyl Acaricide Liquid Formulation for Particle-Size Stability

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Solution Overview

Problem

Existing biphenyl-containing compound formulations face issues with particle size increase due to low melting points, leading to creaming, flocculation, and reduced biological activity, making them unusable in liquid pesticide applications.

Innovation Solution

A liquid formulation of biphenyl-containing compounds using specific carriers and auxiliaries, including a stabilizer like liquiritin, to control particle size and enhance dispersibility, stability, and biological activity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If compound A with melting point 50-60°C is prepared as suspension concentrate according to conventional conditions, then the formulation can be produced, but the particle size increases significantly during heat storage and normal temperature storage, causing creaming, flocculation and reduced biological activity

Engineering Contradiction:

Improveformulation productionVSAvoidparticle size control

Core Design Contradiction:

Ease of manufactureVSManufacturing precision

Solution Approach 1:

The patent changes the physical state parameter of compound A from solid to liquid form, and adjusts the melting point parameter through chemical structure modification. This allows the active ingredient to remain in liquid state at storage temperatures, preventing particle size increase, creaming, and flocculation while maintaining manufacturability of the suspension concentrate formulation

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite liquid formulation by combining liquid compound A with suspension concentrate carriers and adjuvants. This composite system maintains the liquid state of the active ingredient while providing the dispersibility and stability characteristics of suspension concentrates, resolving the contradiction between ease of manufacture and particle size control

Inventive Principle:

Principle #40Composite materials

2Adaptability or versatility

If compound A is formulated as liquid pesticide products including suspension concentrate, emulsion, micro-emulsion or solution, then the formulation can be produced, but the low melting point causes physical property changes during accelerated heat storage test, resulting in creaming, flocculation, crystallization and significant particle size increase

Engineering Contradiction:

Improveformulation typeVSAvoidphysical stability

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent modifies the melting point parameter of compound A through chemical structure changes, transforming it from a solid with melting point 50-60°C to a liquid form. This parameter change ensures the active ingredient remains in liquid state during accelerated heat storage tests, preventing crystallization, creaming, and flocculation across multiple formulation types while maintaining physical stability and reliability

Inventive Principle:

Principle #35Parameter changes

3Ease of manufacture

If compound A is prepared in universal applicable formulation form, then the formulation can be produced easily, but the particle size control is lost and biological activity is obviously influenced or product becomes unusable

Engineering Contradiction:

Improveformulation preparationVSAvoidparticle size control

Core Design Contradiction:

Ease of manufactureVSManufacturing precision

Solution Approach 1:

The patent changes the physical state parameter of compound A to liquid form, which fundamentally alters how the active ingredient behaves in formulation. This parameter change enables simultaneous achievement of easy manufacture and precise particle size control, as the liquid state prevents aggregation and settling that cause particle size increase in conventional solid-based formulations

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The formulation maintains uniform particle size and stability, ensuring excellent acaricidal activity, improved wetting, spreading, and penetration, while being safe for crops and reducing dosage requirements.

Implementation Method 1

The auxiliary in the liquid formulation also comprises a stabilizer, wherein the stabilizer is liquiritin

Methodology Applied

Scientific EffectSteric stabilization:

Implementation Method 2

The liquid formulation of an acaricide is soluble concentrate, oil miscible liquid, spreading oil, dispersible concentrate, emulsion (oil in water), emulsion (water in oil), emulsifiable concentrate, micro-emulsion, suspension concentrate, capsule suspension, oil miscible flowable concentrate, oil-based suspension concentrate, or ultra low volume liquid

Methodology Applied

Scientific EffectSurfactant action: Surfactant

Data Source

PatentUS12446580B2Liquid formulation of biphenyl-containing compound and application thereof

Publication Date: 2025.10.21 JIANGSU YANGNONG CHEM CO LTD

AI summary

The present invention belongs to the field of acaricides, and relates to a liquid formulation of a biphenyl-containing compound and an application thereof. A liquid formulation of a biphenyl-containing compound takes compound A as an active component and comprises at least one carrier and at least one auxiliary. The weight percentage of the active component in the liquid formulation is 0.1%-99%. The liquid formulation of the present invention can control the particle size of the liquid formulation through a good auxiliary system, and has the characteristics of good dispersibility, high suspension rate, good biological activity, low dosage, low cost, resistance to rain washing, low residue and low toxicity to people and animals.