Bipolar High-Voltage Pulse Circuit for Precise Tissue Ablation
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Solution Overview
Problem
Current tissue ablation methods face challenges in precisely targeting and limiting ablation to desired tissues and locations, often resulting in excessive heating and damage to surrounding layers, such as the muscularis during thermal energy application.
Innovation Solution
The development of bipolar high voltage treatment methods and systems that include an electrode for ablation or electroporation, utilizing a power supply capable of producing high voltage bipolar pulses with specific voltage ranges and frequencies to generate an electric field for targeted tissue treatment, while minimizing damage to non-target tissues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If thermal energy is applied to the duodenum for ablation treatment, then tissue ablation is achieved, but excessive heating damages additional layers such as the muscularis
Solution Approach 1:
The patent changes the fundamental parameter of energy delivery from continuous thermal energy to pulsed electrical energy. By using bipolar pulsed electrical fields with specific voltage ranges (e.g., ±200V to ±2000V) and pulse repetition frequencies (>10 kHz), the system achieves ablation through electroporation rather than thermal heating, thereby eliminating damage to surrounding muscularis layers while maintaining precise mucosal targeting
Solution Approach 2:
The patent employs periodic pulsed electrical delivery with controlled pulse widths (e.g., 100 ns to 10 μs) and repetition frequencies (e.g., 1 kHz to 1 MHz). This periodic action allows the tissue to recover between pulses and prevents cumulative thermal damage while maintaining effective electroporation at the target site, thus resolving the contradiction between achieving ablation and avoiding excessive heating
2Manufacturing precision
If high voltage pulses are delivered to achieve precise ablation, then treatment precision is improved, but system complexity increases
Solution Approach 1:
The patent segments the power supply into modular functional blocks: DC voltage sources, energy storage capacitors, high-voltage switching circuits with bipolar transistors or MOSFETs, and control circuitry. This segmentation allows each module to be independently optimized and tested, reducing overall system complexity while enabling precise delivery of bipolar pulsed electrical fields for accurate ablation
Solution Approach 2:
The patent uses parameter changes in the electrical waveform (bipolar pulses with specific amplitudes, widths, and frequencies) to achieve precise ablation control without requiring complex mechanical or structural modifications. By adjusting electrical parameters rather than physical components, the system maintains simplicity while achieving high precision
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These systems effectively deliver precise ablation treatments by generating therapeutic electric fields at specific tissue depths, reducing damage to surrounding tissues and allowing for controlled tissue regeneration, as demonstrated in treating cardiac and gastrointestinal tissues.
Implementation Method 1
specialized multielectrode catheters have been used to deliver electroporation to the ostium of the pulmonary veins within the left atrium
Implementation Method 2
Applying thermal energy to the duodenum can result in excessive heating that damages additional layers of the duodenum
Data Source
AI summary
Bipolar high voltage bipolar pulsing treatment systems, devices, and methods are disclosed that include electrodes for ablation or electroporation and power supplies for supplying bipolar high voltage pulses to the electrode. The power supply includes a DC Source, an energy storage capacitor coupled with the DC source, a first high voltage switch electrically coupled with the DC source and the energy storage capacitor, and a first diode arranged across arranged across the first high voltage switch. In some cases, the power supply can produce high voltage bipolar pulses with a positive high voltage pulse greater than about 200 V followed by a negative high voltage pulse less than about −200 V with a positive to negative dwell period between the positive high voltage pulse and the negative high voltage pulse.