Bi-layer Probiotic Tablet for Targeted GI Delivery
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Solution Overview
Problem
Conventional probiotic dosage forms provide a single mode or rate of release, leading to inefficient delivery of distinct microbes to specific regions of the gastrointestinal tract, as they often result in either uniform release to the wrong region or require multiple dosage forms for targeted delivery.
Innovation Solution
Development of multi-layered or bi-layered acid protective oral dosage formulations with distinct probiotics in each layer, allowing for varied release profiles and targeted delivery to specific regions of the gastrointestinal tract, such as the upper and lower tracts, without the need for enteric coating.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a single mode or rate of release is used in conventional probiotic dosage forms, then the formulation is simple to manufacture, but the delivery efficiency of distinct microbes to specific regions of the gastrointestinal tract is reduced
Solution Approach 1:
The probiotic dosage form is divided into multiple layers, with each layer containing distinct probiotic strains and providing different release profiles (immediate, sustained, or controlled release). This segmentation allows targeted delivery of different microbes to specific regions of the gastrointestinal tract, resolving the contradiction between delivery efficiency and structural complexity.
2Productivity
If multiple dosage forms are used to target different gastrointestinal regions, then targeted delivery of distinct probiotics is achieved, but the ease of operation and patient compliance deteriorate
Solution Approach 1:
Multiple probiotic formulations with different release profiles are merged into a single multi-layered dosage form. This allows patients to take one tablet instead of multiple separate dosage forms, maintaining targeted delivery effectiveness while significantly improving ease of operation and patient compliance.
3Productivity
If uniform release of mixed probiotics is provided, then the dosage form is simple, but certain microbes are delivered to wrong regions reducing effectiveness
Solution Approach 1:
Different layers of the dosage form are assigned different release qualities - some layers provide immediate release for upper GI tract targeting, while others provide sustained or controlled release for lower GI tract targeting. This local differentiation of release properties ensures each probiotic strain is delivered to its optimal region, resolving the contradiction between delivery effectiveness and structural complexity.
Data Source
AI summary
The present invention generally relates to dietary supplement and pharmaceutical formulations comprising layered acid protective oral dosage formulations comprising probiotics and provided as single unified or cohesive dosage form units. Each individual acid protective layer of the cohesive dosage form provides one of a different probiotic payload, a different release profile to target delivery of probiotic to a particular region in the gastrointestinal tract, or both different probiotic payloads and release profiles to target delivery of different probiotics to particular regions in the gastrointestinal tract.