Bis-amide Insecticides with Arylperfluoroalkyl Substituents
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Solution Overview
Problem
Current insecticides lack improved efficacy, selectivity, reduced toxicity, and resistance to pest control, with a need for compounds that offer broader activity and more efficient delivery and retention at pest sites, as well as being more biodegradable.
Innovation Solution
Development of bis-amide derivatives substituted with an arylperfluoroalkyl group and a 4-cyano-phenyl group, which exhibit enhanced insecticidal properties, including improved efficacy, selectivity, and reduced toxicity, and are formulated for efficient delivery and retention.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional insecticides are used, then pest control is achieved, but efficacy and selectivity are insufficient
Solution Approach 1:
The patent modifies the molecular structure of amide compounds by introducing specific substituents (arylperfluoroalkyl groups at positions 2 or 6, and 4-cyano-phenyl groups) to change the chemical parameters of the insecticide, thereby improving both efficacy and selectivity simultaneously
Solution Approach 2:
The invention creates composite molecular structures combining multiple functional groups (amide backbone, arylperfluoroalkyl substituents, cyano-phenyl groups) to achieve synergistic effects that improve both pest control efficacy and selectivity
2Reliability
If conventional insecticides are used, then pest control is achieved, but toxicity is reduced
Solution Approach 1:
The patent introduces specific functional groups at particular positions on the molecular structure (arylperfluoroalkyl at positions 2 or 6, cyano-phenyl at position 4) to localize the biological activity, achieving effective pest control while reducing harmful effects on non-target organisms
3Reliability
If conventional insecticides are used, then pest control is achieved, but resistance development occurs
Solution Approach 1:
The patent changes the chemical parameters of the insecticide by introducing novel substituent patterns (combination of arylperfluoroalkyl and cyano-phenyl groups), creating a new mode of action that pests have not developed resistance against
4Reliability
If conventional insecticides are used, then pest control is achieved, but delivery and retention at pest sites are inefficient
Solution Approach 1:
The patent modifies physical-chemical parameters of the insecticide molecules (lip solubility, vapor pressure, stability) through strategic substituent placement, improving delivery to pest sites and retention at application locations
5Reliability
If conventional insecticides are used, then pest control is achieved, but biodegradability is poor
Solution Approach 1:
The patent balances persistence and biodegradability by selecting specific substituent combinations that maintain sufficient stability for effective pest control while allowing eventual breakdown into harmless substances in the environment
Data Source
AI summary
The present invention relates to novel triazole derivatives of formula (I) having insecticidal activity, to processes and intermediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests; wherein R1, R2, G1, G2, Q1 and Q2 are as defined in claim 1; or salts thereof.